Gene Expression Data
Assay Details
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Assay
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Reference:
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J:245876
Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:7857175
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Gene symbol:
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Atoh1
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Gene name:
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atonal bHLH transcription factor 1
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Probe:
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Atoh1 probe
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Probe preparation:
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labelled with digoxigenin RNA
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Results
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Specimen
4A:
embryonic day 16.5
(more  )
Note: Base of cochlea.
Specimen
4A:
(close  )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4A
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Expression in prosensory domain.
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Specimen
4B:
embryonic day 16.5
(more )
Note: Mid cochlea.
Specimen
4B:
(close )
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Genetic Background:
|
Not Specified
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Age:
|
embryonic day 16.5
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Sex:
|
Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
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|
Embedding:
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Cryosection
|
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Note:
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Mid cochlea.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4B
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Expression in prosensory domain.
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Specimen
4C:
embryonic day 16.5
(more )
Note: Apex of cochlea.
Specimen
4C:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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|
Embedding:
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Cryosection
|
|
Note:
|
Apex of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4C
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Expression in prosensory domain.
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Specimen
4D:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
|
|
Note:
|
Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4D
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Expression in prosensory domain initiated properly at base level of cochlea.
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Specimen
4E:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4E
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Expression in prosensory domain initiated properly at mid level of cochlea.
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Specimen
4F:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
4F
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Expression delayed by ~48 hours compared to control.
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Specimen
S5A:
embryonic day 14.5
(more )
Note: Base of cochlea.
Specimen
S5A:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Base of cochlea.
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Specimen
S5B:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
|
embryonic day 14.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS22: cochlear duct |
Present |
Regionally restricted |
S5B
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Expression initiated properly at base level of cochlea.
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Specimen
S5C:
embryonic day 15.5
(more )
Note: Base of cochlea.
Specimen
S5C:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
|
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Embedding:
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Cryosection
|
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Note:
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Base of cochlea.
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Specimen
S5D:
embryonic day 15.5
(more )
Note: Mid cochlea.
Specimen
S5D:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Note:
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Mid cochlea.
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Specimen
S5E:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlear duct |
Present |
Regionally restricted |
S5E
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Expression initiated properly at base level of cochlea.
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Specimen
S5F:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
|
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlear duct |
Present |
Regionally restricted |
S5F
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Expression initiated properly at mid level of cochlea.
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Specimen
S5G:
embryonic day 16.5
(more )
Note: Base of cochlea.
Specimen
S5G:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
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Specimen
S5H:
embryonic day 16.5
(more )
Note: Mid cochlea.
Specimen
S5H:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
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Mid cochlea.
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Specimen
S5I:
embryonic day 16.5
(more )
Note: Apex of cochlea.
Specimen
S5I:
(close )
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Genetic Background:
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Not Specified
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Age:
|
embryonic day 16.5
|
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
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Embedding:
|
Cryosection
|
|
Note:
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Apex of cochlea.
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Specimen
S5J:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
|
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Mutant Allele(s):
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Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
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Type:
|
section
|
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
S5J
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Expression initiated properly at base level of cochlea.
|
Specimen
S5K:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
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Type:
|
section
|
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Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Present |
Regionally restricted |
S5K
|
Expression initiated properly at mid level of cochlea.
|
Specimen
S5L:
(close )
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Genetic Background:
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involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: cochlear duct |
Ambiguous |
Regionally restricted |
S5L
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Expression delayed by ~48 hours at apex.
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Specimen
S5M:
embryonic day 17.5
(more )
Note: Base of cochlea.
Specimen
S5M:
(close )
|
Genetic Background:
|
Not Specified
|
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Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
Specimen
S5N:
embryonic day 17.5
(more )
Note: Mid cochlea.
Specimen
S5N:
(close )
|
Genetic Background:
|
Not Specified
|
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Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
Specimen
S5O:
embryonic day 17.5
(more )
Note: Apex of cochlea.
Specimen
S5O:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
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Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
Specimen
S5P:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cochlear duct |
Present |
Regionally restricted |
S5P
|
Expression initiated properly at base level of cochlea.
|
Specimen
S5Q:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cochlear duct |
Present |
Regionally restricted |
S5Q
|
Expression initiated properly at mid level of cochlea.
|
Specimen
S5R:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: cochlear duct |
Trace |
Regionally restricted |
S5R
|
Expression delayed by ~48 hours at apex.
|
Specimen
S5S:
embryonic day 18.5
(more )
Note: Base of cochlea.
Specimen
S5S:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
Specimen
S5T:
embryonic day 18.5
(more )
Note: Mid cochlea.
Specimen
S5T:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
Specimen
S5U:
embryonic day 18.5
(more )
Note: Apex of cochlea.
Specimen
S5U:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
Specimen
S5V:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Base of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cochlear duct |
Present |
Regionally restricted |
S5V
|
Expression initiated properly at base level of cochlea.
|
Specimen
S5W:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Mid cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cochlear duct |
Present |
Regionally restricted |
S5W
|
Expression initiated properly at mid level of cochlea.
|
Specimen
S5X:
(close )
|
Genetic Background:
|
involves: 129S4/SvJae * C57BL/6
|
|
Mutant Allele(s):
|
Esrp1tm1.2Rpc/Esrp1tm1.2Rpc
|
|
Age:
|
embryonic day 18.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Cryosection
|
|
Note:
|
Apex of cochlea.
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cochlear duct |
Present |
Regionally restricted |
S5X
|
Expression delayed by ~48 hours at apex.
|
|
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