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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788393
Gene symbol: Tbx1
Gene name: T-box 1
Probe: Tbx1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6D anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D anterior control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen 6D anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D anterior Tbx2/3cDKO Tbx1 Expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis and was abolished from the anterior-dorsal otocyst.
Specimen 6D mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D mid-transverse control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen 6D mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D mid-transverse Tbx2/3cDKO Tbx1 Expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis and was abolished from the anterior-dorsal otocyst.
Specimen 6D posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D posterior control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen 6D posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6D posterior Tbx2/3cDKO Tbx1 Expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis and was abolished from the anterior-dorsal otocyst.
Specimen S4A anterior control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A anterior control Tbx1 Expression was restricted to the posterior-lateral otocyst.
Specimen S4A anterior Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A anterior Tbx2/3cDKO Tbx1 Expression in the posterior-lateral otocyst was unaffected in the Tbx2/3cDKO.
Specimen S4A mid-transverse control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A mid-transverse control Tbx1 Expression was restricted to the posterior-lateral otocyst.
Specimen S4A mid-transverse Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A mid-transverse Tbx2/3cDKO Tbx1 Expression in the posterior-lateral otocyst was unaffected in the Tbx2/3cDKO.
Specimen S4A posterior control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A posterior control Tbx1 Expression was restricted to the posterior-lateral otocyst.
Specimen S4A posterior Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A posterior Tbx2/3cDKO Tbx1 Expression in the posterior-lateral otocyst was unaffected in the Tbx2/3cDKO.
Specimen S4B control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4B control Tbx1 Expression was restricted to the posterior-lateral otocyst.
Specimen S4B Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4B Tbx2/3cDKO Tbx1 Expression in the posterior-lateral otocyst was unaffected in the Tbx2/3cDKO.
Specimen S6A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A anterior control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A anterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A anterior Tbx2cKO Tbx1 In Tbx2cKO embryos, Tbx1 expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis.
Specimen S6A anterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A anterior Tbx3cKO Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A anterior Tbx2/3cDKO Tbx1 In Tbx2/3cDKO mutants, expression of Tbx1 was additionally abolished from the anterior-dorsal otocyst.
Specimen S6A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A mid-transverse control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A mid-transverse Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A mid-transverse Tbx2cKO Tbx1 In Tbx2cKO embryos, Tbx1 expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis.
Specimen S6A mid-transverse Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A mid-transverse Tbx3cKO Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A mid-transverse Tbx2/3cDKO Tbx1 In Tbx2/3cDKO mutants, expression of Tbx1 was additionally abolished from the anterior-dorsal otocyst.
Specimen S6A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A posterior control Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A posterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A posterior Tbx2cKO Tbx1 In Tbx2cKO embryos, Tbx1 expression was absent from the ventral aspect of the otocyst along the complete anterior-posterior axis.
Specimen S6A posterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A posterior Tbx3cKO Tbx1 Expression was detected in the entire otocyst except for the anterior-ventral neurogenic domain.
Specimen S6A posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6A posterior Tbx2/3cDKO Tbx1 In Tbx2/3cDKO mutants, expression of Tbx1 was additionally abolished from the anterior-dorsal otocyst.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory