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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788374
Gene symbol: Neurog1
Gene name: neurogenin 1
Probe: Neurog1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A anterior control Neurog1 Expression was found in the anterior ventro-lateral otocyst.
TS17: acoustic ganglion Present Regionally restricted 6A anterior control Neurog1 Expression was found in the periphery of the statoacoustic ganglion.
Specimen 6A anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A anterior Tbx2/3cDKO Neurog1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen 6A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous 6A mid-transverse control Neurog1 Expression was found in the anterior ventro-lateral otocyst.
Specimen 6A mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A mid-transverse Tbx2/3cDKO Neurog1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen 6A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous 6A posterior control Neurog1 Expression was found in the anterior ventro-lateral otocyst.
Specimen 6A posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A posterior Tbx2/3cDKO Neurog1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen S4A anterior control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A anterior control Neurog1 Expression was found in the ventral region along the anterior-posterior axis at E9.5.
Specimen S4A anterior Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A anterior Tbx2/3cDKO Neurog1 Expression in the ventral region along the anterior-posterior axis at E9.5 was unaffected in the Tbx2/3cDKO.
Specimen S4A mid-transverse control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A mid-transverse control Neurog1 Expression was found in the ventral region along the anterior-posterior axis at E9.5.
Specimen S4A mid-transverse Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A mid-transverse Tbx2/3cDKO Neurog1 Expression in the ventral region along the anterior-posterior axis at E9.5 was unaffected in the Tbx2/3cDKO.
Specimen S4A posterior control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A posterior control Neurog1 Expression was found in the ventral region along the anterior-posterior axis at E9.5.
Specimen S4A posterior Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4A posterior Tbx2/3cDKO Neurog1 Expression in the ventral region along the anterior-posterior axis at E9.5 was unaffected in the Tbx2/3cDKO.
Specimen S4B control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4B control Neurog1 Expression was found in the ventral region.
Specimen S4B Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted S4B Tbx2/3cDKO Neurog1 Expression in the ventral region was unaffected in the Tbx2/3cDKO.
Specimen S5A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5A anterior control Neurog1
Specimen S5A anterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A anterior Tbx2cKO Neurog1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5A mid-transverse control Neurog1
Specimen S5A mid-transverse Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A mid-transverse Tbx2cKO Neurog1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5A posterior control Neurog1
Specimen S5A posterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A posterior Tbx2cKO Neurog1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5B anterior control Neurog1
Specimen S5B anterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5B anterior Tbx3cKO Neurog1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
Specimen S5B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5B mid-transverse control Neurog1
Specimen S5B mid-transverse Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5B mid-transverse Tbx3cKO Neurog1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
Specimen S5B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5B posterior control Neurog1
Specimen S5B posterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5B posterior Tbx3cKO Neurog1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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