Otx2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type:	RNA in situ
MGI Accession ID:	MGI:7788226
Gene symbol:	Otx2
Gene name:	orthodenticle homeobox 2

Probe:	Otx2 probe
Probe preparation:	Antisense labelled with digoxigenin RNA

Results

Specimen 4E control: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: otocyst	Present		4E control Otx2	Expression was detected in the ventro-lateral region.

Specimen 4E Tbx2/3cDKO: embryonic day 10.5; Tbx2^tm2.1Vmc/Tbx2^tm2.1Vmc, Tbx3^tm1Pa/Tbx3^tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: otocyst	Ambiguous		4E Tbx2/3cDKO Otx2	Otx2 expression was completely abolished from the ventro-lateral region in the Tbx2/3cDKO.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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