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Gene Expression Data
Assay Details
Assay
Reference: J:226893 Iwakura T, et al., Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice. Dev Neurobiol. 2013 Jul;73(7):502-17
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7785585
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: Anti-TH
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 5A Male WT: postnatal week 8 (more )
Note: Quantified in Fig 5B.
Structure Level Pattern Image Note
TS28: hypothalamus periventricular zone Weak 5A Male WT
Specimen 5A Male KO: postnatal week 8; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 5B.
Structure Level Pattern Image Note
TS28: hypothalamus periventricular zone Weak 5A Male KO Similar as in the wild-type male.
Specimen 5A Female WT: postnatal week 8 (more )
Note: Quantified in Fig 5B.
Structure Level Pattern Image Note
TS28: hypothalamus periventricular zone Present 5A Female WT The number of positive neurons was much higher than in the wild-type male.
Specimen 5A Female KO: postnatal week 8; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 5B.
Structure Level Pattern Image Note
TS28: hypothalamus periventricular zone Present 5A Female KO Significantly increased number of positive neurons compared with the wild-type female.
Specimen 6A Male WT: embryonic day 15.0 (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS23: hypothalamus periventricular zone Present 6A Male WT
Specimen 6A Male KO: embryonic day 15.0; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS23: hypothalamus periventricular zone Present 6A Male KO Similar as in the wild-type male.
Specimen 6A Female WT: embryonic day 15.0 (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS23: hypothalamus periventricular zone Present 6A Female WT Similar as in the wild-type male.
Specimen 6A Female KO: embryonic day 15.0; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS23: hypothalamus periventricular zone Present 6A Female KO Similar as in the wild-type female.
Specimen 6B Male WT: postnatal day 1 (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 6B Male WT The number of positive neurons was unchanged from E15 to P1, much higher than in the adult male.
Specimen 6B Male KO: postnatal day 1; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 6B Male KO Similar as in the wild-type male.
Specimen 6B Female WT: postnatal day 1 (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 6B Female WT Similar as in the wild-type male. The number of positive neurons was unchanged from E15 to P1. Just a slight decrease in the adult female.
Specimen 6B Female KO: postnatal day 1; Dpysl3tm1Gosh/Dpysl3tm1Gosh (more )
Note: Quantified in Fig 7.
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 6B Female KO Significantly increased number of positive neurons compared with the wild-type female and the mutant male.
Specimen 8C/F: postnatal day 1 (more )
Note: Double labeled: red - Th; green - Dpysl3 (assay MGI:7785587).
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 8F , 8C Coexpressed with Dpysl3/CRMP4.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
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