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Gene Expression Data
Assay Details
Assay
Reference: J:173838 Manuylov NL, et al., Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15;353(2):229-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7783742
Gene symbol: Foxl2
Gene name: forkhead box L2
Antibody: anti-FOXL2
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 10D XY FOG2cKO left: embryonic day 16.5; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - Sox9 (assay MGI:7783652).
Structure Level Pattern Image Note
TS24: gonad Present 10D left Partial sex reversal, with ectopic expression in the mutant.
Specimen 10D XY FOG2cKO right: embryonic day 16.5; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - Sox9 (assay MGI:7783652).
Structure Level Pattern Image Note
TS24: gonad Present 10D right Partial sex reversal, with ectopic expression in the mutant. SOX9 and FOXL2 expression was not segregated spatially, the proteins were not expressed in the same cell.
Specimen 10E XY FOG2cKO left: embryonic day 16.5; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - H2ax (assay MGI:7783743).
Structure Level Pattern Image Note
TS24: gonad Present 10E left Partial sex reversal, with ectopic expression in the mutant.
Specimen 10E XY FOG2cKO right: embryonic day 16.5; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - H2ax (assay MGI:7783743).
Structure Level Pattern Image Note
TS24: gonad Present 10E right Partial sex reversal, with ectopic expression in the mutant.
Specimen S5D/E/F XY FOG2cKO: postnatal day 1; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - Sox9 (assay MGI:7783652).
Structure Level Pattern Image Note
TS27: gonad Present S5D , S5F , S5E Partial sex reversal, with ectopic expression in the mutant.
Specimen S5G XX control: postnatal day 1 (more )
Note: Double labeled: green - Foxl2; red - Sox9 (assay MGI:7783652).
Structure Cell Type Level Pattern Image Note
TS27: ovary follicle cell granulosa cell Present S5G
Specimen S5H XY FOG2cKO: postnatal day 1; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - Ddx4 (assay MGI:7783744).
Structure Level Pattern Image Note
TS27: gonad Present S5H Partial sex reversal, with ectopic expression in the mutant. Germ cells were associated with the remaining testis cords.
Specimen S5I XX control: postnatal day 1 (more )
Note: Double labeled: green - Foxl2; red - Ddx4 (assay MGI:7783744).
Structure Cell Type Level Pattern Image Note
TS27: ovary follicle cell granulosa cell Present S5I
Specimen S5J XY FOG2cKO: postnatal day 21; Tg(Nr5a1-cre)2Klp/0, Zfpm2tm2Sho/Zfpm2tm2Sho (more )
Note: Conditional mutant. Hermaphrodite. Double labeled: green - Foxl2; red - Sox9 (assay MGI:7783652).
Structure Level Pattern Image Note
TS28: gonad Present S5J Despite the overall "ovarian" appearance of the XY mutant gonad, the early stage follicles present in the normal ovary were absent.
Specimen S5L XX control: postnatal day 21 (more )
Note: Double labeled: green - Foxl2; red - Ddx4 (assay MGI:7783744).
Structure Cell Type Level Pattern Image Note
TS28: ovary follicle cell granulosa cell Present S5L
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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