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Gene Expression Data
Assay Details
Assay
Reference: J:125903 Dominguez MG, et al., Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7780057
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: anti-PECAM1
Results
Specimen 2A: embryonic day 9.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS15: head blood vessel Present 2C , 2A
TS15: cardinal vein Present 2A , 2E
Specimen 2B: embryonic day 9.5; Ptprbtm1Gdy/Ptprbtm1Gdy (more )
Structure Level Pattern Image Note
TS15: head blood vessel Present 2D , 2B Mutant embryos displayed vascular defects.
TS15: venous blood vessel Present 2F , 2B The cardinal vein did not form correctly in the mutant.
Specimen 2G: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: cardinal vein Present 2G
TS14: dorsal aorta Present 2G
Specimen 2H: embryonic day 9.0; Ptprbtm1Gdy/Ptprbtm1Gdy (more )
Structure Level Pattern Image Note
TS14: dorsal aorta Present 2H The dorsal aorta was small and collapsed in the mutant.
TS14: venous blood vessel Present 2H The cardinal veins were diffuse and not clearly delineated.
Specimen 3C: embryonic day 9.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Cell Type Level Pattern Image Note
TS15: yolk sac blood vessel blood vessel endothelial cell Present 3C
Specimen 3D: embryonic day 9.5; Ptprbtm1Gdy/Ptprbtm1Gdy (more )
Structure Level Pattern Image Note
TS15: yolk sac Present Regionally restricted 3D Only a primitive vascular plexus formed in the mutant yolk sac. The vessels in the plexus merge together.
Specimen 3E: embryonic day 9.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present 3E
Specimen 3F: embryonic day 9.5; Ptprbtm1Gdy/Ptprbtm1Gdy (more )
Structure Level Pattern Image Note
TS15: yolk sac Present Regionally restricted 3F Only a primitive vascular plexus formed in the mutant yolk sac. The vessels in the plexus merge together and expand to the point of almost separating the endoderm and mesoderm layers.
Specimen 5C: embryonic day 9.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS15: atrioventricular canal Present 5C
TS15: heart atrium Present 5C
TS15: primitive ventricle Present 5C
Specimen 5D: embryonic day 9.5; Ptprbtm1Gdy/Ptprbtm1Gdy (more )
Structure Level Pattern Image Note
TS15: atrioventricular canal Present 5D
TS15: primitive ventricle Present 5D
TS15: heart atrium Absent 5D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory