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Gene Expression Data
Assay Details
Assay
Reference: J:175534 Sipe CW, et al., Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development. 2011 Aug;138(16):3441-9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7778315
Gene symbol: Fzd3
Gene name: frizzled class receptor 3
Antibody: anti-frizzled 3
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen S2A: embryonic day 17.5 (more )
Note: Double labeled: red - Fzd3; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS25: organ of Corti auditory epithelial supporting cell Present S2A , S2C Expression is enriched on the medial side of plasma membrane in hair cells and support cells.
TS25: organ of Corti auditory hair cell Present S2A , S2C Expression is enriched on the medial side of plasma membrane in hair cells and support cells.
Specimen S2B: embryonic day 17.5; Foxg1tm1(cre)Skm/Foxg1+, Kif3atm2Gsn/Kif3atm2Gsn (more )
Note: Conditional mutant. Double labeled: red - Fzd3; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS25: organ of Corti auditory epithelial supporting cell Present S2D , S2B In the basal region of this mutant protein localization was largely normal.
TS25: organ of Corti auditory hair cell Present S2D , S2B In the basal region of this mutant protein localization was largely normal.
Specimen S2E: embryonic day 17.5 (more )
Note: Double labeled: red - Fzd3; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS25: organ of Corti auditory epithelial supporting cell Present S2G , S2E Expression is enriched on the medial side of plasma membrane in hair cells and support cells.
TS25: organ of Corti auditory hair cell Present S2G , S2E Expression is enriched on the medial side of plasma membrane in hair cells and support cells.
Specimen S2F: embryonic day 17.5; Foxg1tm1(cre)Skm/Foxg1+, Kif3atm2Gsn/Kif3atm2Gsn (more )
Note: Conditional mutant. Double labeled: red - Fzd3; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS25: organ of Corti auditory epithelial supporting cell Present S2F , S2H Toward the apex in this mutant there is asymmetric membrane localization.
TS25: organ of Corti auditory hair cell Present S2F , S2H Toward the apex in this mutant there is asymmetric membrane localization.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory