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Gene Expression Data
Assay Details
Assay
Reference: J:173598 Jacquet BV, et al., Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb. J Neurosci. 2011 Jun 22;31(25):9368-82
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7764097
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-Tbr1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2B +/+: postnatal day 21 (more )
Note: Double labeled: green - Tbr1; red - Nissl.
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present 2B +/+ Tbr1
TS28: main olfactory bulb layer Present 2B +/+ Tbr1
Specimen 2B -/-: postnatal day 21; Foxj1tm1Slb/Foxj1tm1Slb (more )
Note: Double labeled: green - Tbr1; red - Nissl.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Weak 2B -/- Tbr1 Massive depletion of positive neurons and nearly absence of the glomerular layer were seen.
Specimen 2G +/+: postnatal day 6 (more )
Note: Double labeled: green - Tbr1; red - Nissl.
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present 2G +/+ Tbr1
TS28: main olfactory bulb layer Present 2G +/+ Tbr1
Specimen 2G -/-: postnatal day 6; Foxj1tm1Slb/Foxj1tm1Slb (more )
Note: Double labeled: green - Tbr1; red - Nissl.
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present 2G -/- Tbr1 Decreased expression and significantly smaller compared with the wild-type.
TS28: main olfactory bulb layer Present 2G -/- Tbr1 Decreased expression and significantly smaller compared with the wild-type.
Specimen 10A GL/EPL: postnatal day 21; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Double labeled: green - Tbr1; red - Cre reporter.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present 10A left-1 Coexpressed with tdTomato (nearly half of the Foxj1-derived cells) in the superficial layers.
Specimen 10B GL/EPL: postnatal day 90; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Double labeled: green - Tbr1; red - Cre reporter.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present 10B-1 Coexpressed with tdTomato persisted in the superficial layers.
Specimen 11A BrdU-E12.5: postnatal day 21; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Cre reporter; blue - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present Regionally restricted 11A E12.5 Expressed in the superficial layers.
Specimen 11A BrdU-E16.5: postnatal day 21; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Cre reporter; blue - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present Regionally restricted 11A E16.5 Expressed in the superficial layers.
Specimen 11A BrdU-P0: postnatal day 21; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Cre reporter; blue - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present Regionally restricted 11A P0 Expressed in the superficial layers.
Specimen 11A BrdU-P14: postnatal day 21; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(FOXJ1-cre)F26Htzm/0 (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Cre reporter; blue - BrdU.
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present Regionally restricted 11A P14 Expressed in the superficial layers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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