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Gene Expression Data
Assay Details
Assay
Reference: J:62879 Tevosian SG, et al., FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39
Assay type: RNA in situ
MGI Accession ID: MGI:7763952
Gene symbol: Hand1
Gene name: heart and neural crest derivatives expressed 1
Probe: eHAND probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3Ba +/+: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: left ventricle cardiac muscle Present Regionally restricted 3Ba +/+ Highest levels of expression in outer myocardial layer of left and right ventricles.
TS20: right ventricle cardiac muscle Present Regionally restricted 3Ba +/+ Highest levels of expression in outer myocardial layer of left and right ventricles.
TS20: outflow tract Present 3Ba +/+

Specimen 3Ba -/-: embryonic day 12.5; Zfpm2tm1Sho/Zfpm2tm1Sho (more )
Structure Level Pattern Image Note
TS20: heart Weak Regionally restricted 3Ba -/- Expression visibly downregulated compared to wild type. No enhancement of expression along outer curvature.

Specimen 3Bb +/+: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: left ventricle cardiac muscle Present Regionally restricted 3Bb +/+ Highest levels of expression in outer myocardial layer of left and right ventricles.
TS20: right ventricle cardiac muscle Present Regionally restricted 3Bb +/+ Highest levels of expression in outer myocardial layer of left and right ventricles.
TS20: outflow tract Present 3Bb +/+

Specimen 3Bb -/-: embryonic day 12.5; Zfpm2tm1Sho/Zfpm2tm1Sho (more )
Structure Level Pattern Image Note
TS20: heart Weak Regionally restricted 3Bb -/- Expression visibly downregulated compared to wild type. No enhancement of expression along outer curvature.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory