Pou3f3 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:74989 McEvilly RJ, et al., Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002 Feb 22;295(5559):1528-32
Assay type:	RNA in situ
MGI Accession ID:	MGI:7751260
Gene symbol:	Pou3f3
Gene name:	POU domain, class 3, transcription factor 3

Probe:

Brn-1 probe

Results

Specimen S1E WT: postnatal day 0 (more

)

Structure	Level	Image
TS27: cerebral cortex ventricular zone	Present	S1E WT
TS27: cortical plate	Present	S1E WT
TS27: hippocampus CA1	Present	S1E WT

Specimen S1E Brn-1-/-: postnatal day 0; Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Image
TS27: cerebral cortex ventricular zone	Present	S1E Brn-1-/-
TS27: cortical plate	Present	S1E Brn-1-/-
TS27: hippocampus CA1	Present	S1E Brn-1-/-

Specimen S1E Brn-1-/-/Brn-2-/-: postnatal day 0; Pou3f2^tm1Rsd/Pou3f2^tm1Rsd, Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Image
TS27: cerebral cortex ventricular zone	Present	S1E Brn-1-/-/Brn-2-/-
TS27: cortical plate	Present	S1E Brn-1-/-/Brn-2-/-
TS27: hippocampus CA1	Present	S1E Brn-1-/-/Brn-2-/-

Specimen 2A WT: postnatal day 0 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: hippocampus CA1	hippocampal pyramidal neuron	Present	Regionally restricted	2A Brn-1 WT	Expression in pyramidal neurons of CA1 field and adjacent transitional cortex.
TS27: cerebral cortex		Present	Regionally restricted	2A Brn-1 WT	Expression in migrating neurons distributed between ventricular zone and CA1 field.

Specimen 2A Brn-1-/-: postnatal day 0; Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS27: hippocampus	Present	Regionally restricted	2A Brn-1 Brn-1-/-	Expression in neurons accumulating as an ectopically potitioned layer of densely packed cell bodies in hippocapmpus,

Specimen 2A Brn-1-/-/Brn-2-/-: postnatal day 0; Pou3f2^tm1Rsd/Pou3f2^tm1Rsd, Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS27: hippocampus	Present	Regionally restricted	2A Brn-1 Brn-1-/-/Brn-2-/-	Expression in neurons accumulating as an ectopically potitioned layer of densely packed cell bodies in hippocapmpus,

Specimen 2B WT: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: cortical plate	Present		2B Brn-1 WT

Specimen 2B Brn-1-/-: postnatal day 0; Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS27: neocortex	Present		2B Brn-1 Brn-1-/-	Authors state migration defect limited to hippocampus.

Specimen 2B Brn-1-/-/Brn-2-/-: postnatal day 0; Pou3f2^tm1Rsd/Pou3f2^tm1Rsd, Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS27: neocortex	Present	Regionally restricted	2B Brn-1 Brn-1-/-/Brn-2-/-	Expression largely concentrated between ventricular zone and subplate.

Specimen S4A Brn-1 WT: embryonic day 18.0 (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Present		S4A Brn-1 WT

Specimen S4A Brn-1 Brn-1-/-: embryonic day 18.0; Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Present		S4A Brn-1 Brn-1-/-

Specimen S4A Brn-1 Brn-1-/-/Brn-2-/-: embryonic day 18.0; Pou3f2^tm1Rsd/Pou3f2^tm1Rsd, Pou3f3^tm1Rmc/Pou3f3^tm1Rmc (more

)

Structure	Level	Pattern	Image	Note
TS26: neocortex	Present		S4A Brn-1 Brn-1-/-/Brn-2-/-

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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