Th Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:353281 Rybiczka-Tesulov M, et al., Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nat Commun. 2024 Aug 8;15(1):6773
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7738731
Gene symbol:	Th
Gene name:	tyrosine hydroxylase

Antibody:	anti-TH (#AB152)
Detection system:	Secondary antibody coupled to Alexa Fluor
Assay notes:	Another antibody (MGI:1337599) was mentioned in the paper. It was not specified which one was used.

Results

1c E12 ©

Specimen 1c E12: embryonic day 12.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS20: midbrain	midbrain dopaminergic neuron	Present	Regionally restricted	1c E12	Expressed in the dorsal midbrain. Positive axons growing towards the habenula were shown by arrows.

1c E13 ©

Specimen 1c E13: embryonic day 13.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: midbrain	midbrain dopaminergic neuron	Present	Regionally restricted	1c E13	Expressed mainly in the dorsal midbrain. Positive axons growing towards the habenula were shown by arrows.
TS21: forebrain		Present	Regionally restricted	1c E13	Expressed in the medial forebrain bundle.

1c E15 ©

Specimen 1c E15: embryonic day 15.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS23: forebrain		Present	Regionally restricted	1c E15	Expressed in the medial forebrain bundle.
TS23: midbrain	midbrain dopaminergic neuron	Present	Regionally restricted	1c E15	Expressed in the substantia nigra pars compacta and ventral tegmental area.
TS23: corpus striatum		Present		1c E15

1c E18 ©

Specimen 1c E18: embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: midbrain	midbrain dopaminergic neuron	Present	Regionally restricted	1c E18	Expressed mainly in the dorsal midbrain.
TS26: corpus striatum		Present		1c E18
TS26: forebrain		Present	Regionally restricted	1c E18	Expressed in the medial forebrain bundle.

7f merge ©

Specimen 7f: embryonic day 14.5 (more

)
Note: Double labeled: green - Th; purple - Rmst (assay MGI:7738852).

Structure	Cell Type	Level	Pattern	Image	Note
TS22: midbrain	midbrain dopaminergic neuron	Present	Regionally restricted	7f merge	Expressed in the ventral tegmental area and substantia nigra pars compacta.

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