Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:44286
Liebl DJ, et al., Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997 Dec 1;17(23):9113-21
|
|
Assay type:
|
RNA in situ
|
|
MGI Accession ID:
|
MGI:7734690
|
|
Gene symbol:
|
Ntrk1
|
|
Gene name:
|
neurotrophic tyrosine kinase, receptor, type 1
|
|
Probe:
|
TrkA probe
|
|
Probe preparation:
|
Antisense labelled with S35 RNA
|
|
|
Results
|
Specimen
wild type TG:
postnatal newborn
(more  )
Specimen
wild type TG:
(close  )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: trigeminal ganglion |
trigeminal neuron |
Present |
|
|
In wild-type trigeminal ganglion, ~90% of the neurons express Ntrk1.
|
Specimen
BDNF-/- TG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Bdnftm1Par/Bdnftm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: trigeminal ganglion |
trigeminal neuron |
Present |
Regionally restricted |
|
BDNF mutant mice have an ~20-30% Ntrk1-expressing neuron reduction.
|
Specimen
NT-3-/- TG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Ntf3tm1Par/Ntf3tm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: trigeminal ganglion |
trigeminal neuron |
Present |
Regionally restricted |
|
NT-3 mutant mice have an 70-80% Ntrk1-expressing neuron reduction.
|
Specimen
DKO TG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Bdnftm1Par/Bdnftm1Par
Ntf3tm1Par/Ntf3tm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
wild type DRG:
postnatal newborn
(more )
Specimen
wild type DRG:
(close )
|
Genetic Background:
|
Not Specified
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
peripheral nervous system neuron |
Present |
Regionally restricted |
|
In wild-type dorsal root ganglion ~90% of the neurons express Ntrk1.
|
Specimen
BDNF-/- DRG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Bdnftm1Par/Bdnftm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
peripheral nervous system neuron |
Present |
Regionally restricted |
|
BDNF mutant mice have an ~20-30% Ntrk1-expressing neuron reduction.
|
Specimen
NT-3-/- DRG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Ntf3tm1Par/Ntf3tm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
peripheral nervous system neuron |
Present |
Regionally restricted |
|
NT-3 mutant mice have an 70-80% Ntrk1-expressing neuron reduction.
|
Specimen
DKO DRG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv
|
|
Mutant Allele(s):
|
Bdnftm1Par/Bdnftm1Par
Ntf3tm1Par/Ntf3tm1Par
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
|
Analysis Tools
