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Gene Expression Data
Assay Details
Assay
Reference: J:171072 Carre A, et al., Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. PLoS One. 2011;6(2):e16752
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7720372
Gene symbol: Hes1
Gene name: hes family bHLH transcription factor 1
Antibody: anti-Hes1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 1E/H: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: thyroid primordium Present Regionally restricted 1H , 1E Only expressed in a subset of Nkx2-1-positive precursors of the median anlage.
TS15: foregut Present Regionally restricted 1H , 1E Expressed in the thyroid anlagen surrounding tissues.
Specimen 1F/I: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: thyroid gland Present Regionally restricted 1I , 1F Expressed in the median anlage lining the aortic sac.
TS19: foregut Present Regionally restricted 1F Expressed in the thyroid anlagen surrounding tissues.
Specimen 1G/J: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: thyroid gland Present Regionally restricted 1G , 1J Expressed in the ultimobranchial bodies in a lateral position.
TS19: foregut Present Regionally restricted 1G Expressed in the thyroid anlagen surrounding tissues.
Specimen 1L: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: thyroid gland Present 1L Expressed in Ascl1/Mash1-positive cells (compared with Fig 1P).
Specimen 1M/Q/R: embryonic day 17.5 (more )
Note: Double labeled: brown - Hes1; red - Tg (assay MGI:7720377).
Structure Cell Type Level Pattern Image Note
TS25: thyroid gland thyroid follicular cell Present 1Q , 1R , 1M Expressed in TG-producing thyrocytes within thyroid follicles.
TS25: thyroid gland parafollicular cell Present 1M , 1R Expressed in calcitonin-producing C-cells (compared with Fig 1N/S).
Specimen 1O/T: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: thyroid gland Present 1T , 1O Expressed in some Nkx2-1-positive cells (compared with Fig 1K).
Specimen S1B +/+: embryonic day 10.5 (more )
Note: Double labeled: brown - Hes1; red - Nkx2-1 (assay MGI:7720371).
Structure Level Pattern Image Note
TS17: thyroid primordium Present S1B-1 , S1B-4 , S1B-3
Specimen S1B -/-: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Note: Double labeled: brown - Hes1; red - Nkx2-1 (assay MGI:7720371).
Structure Level Pattern Image Note
TS17: thyroid primordium Absent S1B-5 , S1B-7 , S1B-8
Specimen not shown: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: thyroid gland thyroid follicular cell Present Nuclear staining in most Nkx2-1-positive cells and TG-producing thyrocytes within thyroid follicles.
TS23: thyroid gland parafollicular cell Present Expressed in calcitonin-producing C-cells.
Specimen not shown: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: thyroid gland thyroid follicular cell Present Nuclear staining in most Nkx2-1-positive cells and TG-producing thyrocytes within thyroid follicles.
Specimen not shown: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: thyroid gland follicle thyroid follicular cell Present Nuclear staining in most Nkx2-1-positive cells and TG-producing thyrocytes within thyroid follicles.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory