Gcg Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:62595 Jacquemin P, et al., Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7718630
Gene symbol:	Gcg
Gene name:	glucagon

Antibody:	anti-GLU 001
Detection system:	Secondary antibody

Results

Specimen 3A: postnatal week 5 (more

)
Note: Genetic background of control was either wild type or heterozygous. Double labeled: green - Gcg; red - Ins1 (assay MGI:7718634) and Ins2 (assay MGI:7718635).

Structure	Level	Pattern	Image	Note
TS28: pancreatic islet mantle	Present	Regionally restricted	3A	Mantle of Gcg-expressing cells around insulin-expressing cells.

Specimen 3B: postnatal week 5; Onecut1^tm1Flem/Onecut1^tm1Flem (more

)
Note: Double labeled: green - Gcg; red - Ins1 (assay MGI:7718634) and Ins2 (assay MGI:7718635).

Structure	Level	Pattern	Image	Note
TS28: islets of Langerhans	Present	Regionally restricted	3B	Islets with perturbed architecture. No mantle of Gcg-expressing cells around insulin-expressing cells. Expression in a few cells in epithelium of cysts.

Specimen not shown: postnatal week 10; Onecut1^tm1Flem/Onecut1^tm1Flem (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: islets of Langerhans	pancreatic A cell	Present	Scattered		Expression in alpha cells scattered throughout islets.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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