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Gene Expression Data
Assay Details
Assay
Reference: J:350071 Aaron KA, et al., Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea. Mol Ther Methods Clin Dev. 2023 Sep 14;30:413-428
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7717779
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 1D: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1D lower
TS28: organ of Corti external pillar cell of cochlea Present 1D lower
TS28: organ of Corti inner phalangeal cell Present 1D lower
TS28: organ of Corti internal pillar cell of cochlea Present 1D lower
Specimen 1E: postnatal day 12; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1E lower Similar as in the wild-type.
TS28: organ of Corti external pillar cell of cochlea Present 1E lower Similar as in the wild-type.
TS28: organ of Corti inner phalangeal cell Present 1E lower Similar as in the wild-type.
TS28: organ of Corti internal pillar cell of cochlea Present 1E lower Similar as in the wild-type.
Specimen 1F: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1F lower Similar as in the wild-type.
TS28: organ of Corti external pillar cell of cochlea Present 1F lower Similar as in the wild-type.
TS28: organ of Corti inner phalangeal cell Present 1F lower Similar as in the wild-type.
TS28: organ of Corti internal pillar cell of cochlea Present 1F lower Similar as in the wild-type.
Specimen 1G: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1G lower
TS28: organ of Corti external pillar cell of cochlea Present 1G lower
TS28: organ of Corti inner phalangeal cell Present 1G lower
TS28: organ of Corti internal pillar cell of cochlea Present 1G lower
Specimen 1H: postnatal day 21; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1H lower Similar as in the wild-type.
TS28: organ of Corti external pillar cell of cochlea Present 1H lower Similar as in the wild-type.
TS28: organ of Corti inner phalangeal cell Present 1H lower Similar as in the wild-type.
TS28: organ of Corti internal pillar cell of cochlea Present 1H lower Similar as in the wild-type.
Specimen 1I: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present 1I lower Positive supporting cells appeared disorganized.
Specimen 1J: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1J lower
TS28: organ of Corti external pillar cell of cochlea Present 1J lower
TS28: organ of Corti inner phalangeal cell Present 1J lower
TS28: organ of Corti internal pillar cell of cochlea Present 1J lower
Specimen 1K: postnatal day 120; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Deiter's cell Present 1K lower Similar as in the wild-type.
TS28: organ of Corti external pillar cell of cochlea Present 1K lower Similar as in the wild-type.
TS28: organ of Corti inner phalangeal cell Present 1K lower Similar as in the wild-type.
TS28: organ of Corti internal pillar cell of cochlea Present 1K lower Similar as in the wild-type.
Specimen 1L: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present 1L lower There was a moderate and variable degree of supporting cell loss (summarized in Table S1) and appeared disorganized.
Specimen S1Q: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1Q
Specimen S1R: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1R Similar as in the wild-type.
Specimen S1S: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1S Disorganized supporting cells were seen.
Specimen S1T: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1T Disorganized supporting cells were seen.
Specimen S1U: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1U Disorganized supporting cells were seen.
Specimen S1V: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: red - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1V Disorganized supporting cells were seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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