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Gene Expression Data
Assay Details
Assay
Reference: J:244304 Richardson R, et al., p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7713273
Gene symbol: Trp63
Gene name: transformation related protein 63
Antibody: 4A4
Results
Specimen 1D: embryonic day 14.5 (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS22: palatal shelf epithelium basal cell of epidermis Present Regionally restricted 1D Expression was down-regulated in the medial edge epithelial cells which cease proliferation and undergo apoptosis.
Specimen 1E: embryonic day 14.5; Tgfb3tm1Doe/Tgfb3tm1Doe (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS22: palatal shelf epithelium basal cell of epidermis Present 1E Expression persisted in the basal cells of the epithelia of the cleft palatal shelves.
Specimen 1F: embryonic day 14.5; Tgfb3tm1Doe/Tgfb3tm1Doe, Trp63tm1Fmc/Trp63+ (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS22: palatal shelf epithelium basal cell of epidermis Present Regionally restricted 1F Embryos had formed, with no apparent positive staining observed in, the midline seam.
Specimen S1D: embryonic day 13.5 (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS21: palatal shelf epithelium basal cell of epidermis Present S1D There was no evidence of cell death.
Specimen S1E: embryonic day 13.5; Tgfb3tm1Doe/Tgfb3tm1Doe (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS21: palatal shelf epithelium basal cell of epidermis Present S1E There was no evidence of cell death, similar as in the wild-type.
Specimen S1F: embryonic day 13.5; Tgfb3tm1Doe/Tgfb3tm1Doe, Trp63tm1Fmc/Trp63+ (more )
Note: Double labeled: red - Trp63; green - Casp3 (assay MGI:7713267).
Structure Cell Type Level Pattern Image Note
TS21: palatal shelf epithelium basal cell of epidermis Present S1F There was no evidence of cell death, similar as in the wild-type.
Specimen S5G: embryonic day 13.5 (more )
Structure Cell Type Level Pattern Image Note
TS21: palatal shelf epithelium basal cell of epidermis Present S5G
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory