Lhx6 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:269929 Elbert A, et al., CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. J Neurosci. 2019 Jan 2;39(1):177-192
Assay type:	RNA in situ
MGI Accession ID:	MGI:7711342
Gene symbol:	Lhx6
Gene name:	LIM homeobox protein 6

Probe:	Lhx6 probe
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

2B control ©

Specimen 2B control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		2B control

2B cKO ©

Specimen 2B Ctcf Nes-Cre: embryonic day 13.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		2B cKO	Decreased expression compared with the control. In a subset of embryos, the reduction in expression was restricted to the caudal region.

2D Puma-/- ©

Specimen 2D Puma-/-: embryonic day 13.5; Bbc3^tm1Ast/Bbc3^tm1Ast (more

)

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		2D Puma-/-

Specimen 2D Ctcf Nes-Cre;Puma-/-: embryonic day 13.5; Bbc3^tm1Ast/Bbc3^tm1Ast, Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		2D cKO;Puma-/-	Decreased expression compared with the control. Preventing apoptosis of cells via removal of PUMA/Bbc3 failed to rescue the change.

2G-1 ©

Specimen 2G control rostral: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: medial ganglionic eminence	Present		2G-1

2G-2 ©

Specimen 2G Ctcf Nes-Cre rostral: embryonic day 12.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: medial ganglionic eminence	Present		2G-2	A subtle decrease compared with control.

2G-3 ©

Specimen 2G control caudal: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: medial ganglionic eminence	Present		2G-3

2G-4 ©

Specimen 2G Ctcf Nes-Cre caudal: embryonic day 12.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: medial ganglionic eminence	Present		2G-4	A subtle decrease compared with control.

5C control ©

Specimen 5C control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		5C control

5C cKO ©

Specimen 5C Ctcf Nkx-Cre: embryonic day 13.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nkx2-1-cre)2Sand/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: medial ganglionic eminence	Present		5C cKO	Decreased expression compared with the control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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