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Gene Expression Data
Assay Details
Assay
Reference: J:57342 Nishino J, et al., GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Neuron. 1999 Aug;23(4):725-36
Assay type: RNA in situ
MGI Accession ID: MGI:7711131
Gene symbol: Th
Gene name: tyrosine hydroxylase
Probe: Th probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 6B: embryonic day 12.5 (more )
Note: Double labeled: blue - Th; blue - Ret (assay MGI:7711127).
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 6B Expression in developing superior cervical ganglion. SCG precursors located between cervical vertebra levels C1 and C7.
Specimen 6C: embryonic day 14.5 (more )
Note: Double labeled: blue - Th; blue - Dbh (assay MGI:7711132).
Structure Level Pattern Image Note
TS22: superior cervical ganglion Present 6C SCG precursors located between cervical vertebra levels C1 and C4.
TS22: cervico-thoracic ganglion Present 6C Stellate ganglion clearly separated from SCG.
Specimen 6E: embryonic day 12.5; Gfra3tm1Hmd/Gfra3tm1Hmd (more )
Note: Double labeled: blue - Th; blue - Ret (assay MGI:7711127).
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 6E Author report caudal shift. Number of prospective SCG neurons 70% compared to wild type levels, and located between C5 and C7.
Specimen 6F: embryonic day 14.5; Gfra3tm1Hmd/Gfra3tm1Hmd (more )
Note: Double labeled: blue - Th; blue - Dbh (assay MGI:7711132).
Structure Level Pattern Image Note
TS22: superior cervical ganglion Present Regionally restricted 6F Author report caudal shift. Number of SCG neurons reduced to 60% of wild type levels, and located mostly between C5 and C7.
TS22: cervico-thoracic ganglion Present 6F Future stellate ganglion is positioned normally.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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