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Gene Expression Data
Assay Details
Assay
Reference: J:290262 Kodama Y, et al., Hmga2 regulation of tooth formation and association with Sox2 and Nanog expression. Biochem Biophys Res Commun. 2019 Feb 19;509(4):1008-1014
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7709147
Gene symbol: Hmga2
Gene name: high mobility group AT-hook 2
Antibody: Anti-Hmga2
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 1C E12: embryonic day 12.0 (more )
Note: initiation stage of tooth germ
Structure Level Pattern Image Note
TS20: oral epithelium Present Widespread 1C lower 12 dpc Widespread expression in primitive mouth epithelium.
TS20: dental placode Present Widespread 1C lower 12 dpc
TS20: oral region mesenchyme Present Regionally restricted 1C lower 12 dpc Expression was detected in the underlying mesenchyme of the dental placode.
Specimen 1C E13: embryonic day 13.0 (more )
Note: bud stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS21: dental placode Present 1C lower 13 dpc
TS21: molar dental lamina Present 1C lower 13 dpc
TS21: lower jaw mesenchyme mesenchymal cell Weak Regionally restricted 1C lower 13 dpc Mesenchymal cells juxtaposing to dental lamina were marginally stained.
Specimen 1C E14: embryonic day 14.0 (more )
Note: cap stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS22: enamel organ Present Regionally restricted 1C lower 14 dpc Expression in enamel organ was deflected on the lingual side.
TS22: dental papilla Weak Regionally restricted 1C lower 14 dpc Dental papilla cells bounded by inner enamel epithelium were marginally stained.
TS22: lower jaw molar mesenchyme mesenchymal cell Weak Regionally restricted 1C lower 14 dpc Mesenchymal cells away from the enamel organ were marginally stained.
TS22: dental sac Present Regionally restricted 1C lower 14 dpc Staining was detected in dental follicle cells that were arranged in lamina surrounding the enamel organ.
Specimen 1C E15: embryonic day 15.0 (more )
Note: cap stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS23: enamel organ Present Regionally restricted 1C lower 15 dpc Expression in enamel organ was deflected on the lingual side.
TS23: dental papilla Weak Regionally restricted 1C lower 15 dpc Dental papilla cells bounded by inner enamel epithelium were marginally stained.
TS23: lower jaw molar mesenchyme mesenchymal cell Weak Regionally restricted 1C lower 15 dpc Mesenchymal cells away from the enamel organ were marginally stained.
TS23: dental sac Present Regionally restricted 1C lower 15 dpc Staining was detected in dental follicle cells that were arranged in lamina surrounding the enamel organ.
Specimen 1C E16: embryonic day 16.0 (more )
Note: bell stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS24: enamel organ Strong Regionally restricted 1C lower 16 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS24: outer enamel epithelium Strong Regionally restricted 1C lower 16 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS24: inner enamel epithelium epithelial cell Weak 1C lower 16 dpc
TS24: cervical loop Present 1C lower 16 dpc
TS24: dental sac Present 1C lower 16 dpc
TS24: lower jaw molar mesenchyme Ambiguous Regionally restricted 1C lower 16 dpc A rapid loss of the surrounding mesenchyme staining was noted.
Specimen 1C E17: embryonic day 17.0 (more )
Note: bell stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS25: enamel organ Strong Regionally restricted 1C lower 17 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS25: outer enamel epithelium Strong Regionally restricted 1C lower 17 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS25: inner enamel epithelium epithelial cell Weak 1C lower 17 dpc
TS25: cervical loop Present 1C lower 17 dpc
TS25: dental sac Present 1C lower 17 dpc
TS25: lower jaw molar mesenchyme Ambiguous 1C lower 17 dpc A rapid loss of the surrounding mesenchyme staining was noted.
Specimen 1C E18: embryonic day 18.0 (more )
Note: bell stage of tooth germ
Structure Cell Type Level Pattern Image Note
TS26: enamel organ Strong Regionally restricted 1C lower 18 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS26: outer enamel epithelium Strong Regionally restricted 1C lower 18 dpc Staining in enamel organ on the lingual side, especially outer enamel epithelium, was most prominent.
TS26: inner enamel epithelium epithelial cell Weak 1C lower 18 dpc
TS26: cervical loop Present 1C lower 18 dpc
TS26: dental sac Present 1C lower 18 dpc
TS26: lower jaw molar mesenchyme Ambiguous 1C lower 18 dpc A rapid loss of the surrounding mesenchyme staining was noted.
Specimen 1C NB: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: lower jaw 1st molar Weak 1C lower NB
Specimen 1C 1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: lower jaw 1st molar Weak 1C lower 1 pp
Specimen 1C 2: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: lower jaw 1st molar Weak 1C lower 2 pp
Specimen 1C 3: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: lower jaw 1st molar Weak 1C lower 3 pp
Specimen 1C 4: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: lower jaw 1st molar Weak 1C lower 4 pp
Specimen 1C 5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: lower jaw 1st molar Weak 1C lower 5 pp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory