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Gene Expression Data
Assay Details
Assay
Reference: J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7666668
Gene symbol: Col1a1
Gene name: collagen, type I, alpha 1
Antibody: anti-Col1 (ab34710)
Assay notes: The specificity of the antibody used was not detailed; both family members have been annotated MGI:7666677.
Results
Specimen 5A E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: atrioventricular endocardial cushion Weak 5A E10.5
Specimen 5A E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Weak 5A E11.5
Specimen 5A E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: atrioventricular endocardial cushion Present 5A E12.5 Beginning at E12.5, expression in the cushion mesenchyme was prominent.
Specimen 5A E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: atrioventricular valve Strong 5A E13.5 Expression persists at a high level from E13.5-16.5.
Specimen 5A E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: atrioventricular valve Strong 5A E14.5 Expression persists at a high level from E13.5-16.5.
Specimen 5A E15.5s: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: atrioventricular valve Strong 5A E15.5 Expression persists at a high level from E13.5-16.5.
Specimen 5A E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: atrioventricular valve Strong 5A E16.5 Expression persists at a high level from E13.5-16.5.
Specimen 6B Control: embryonic day 13.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS21: atrioventricular endocardial cushion Present Regionally restricted 6B Control Expression was detected in distinct fibrous networks in the remodeling atrioventricular valves.
Specimen 6B DKO: embryonic day 13.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: atrioventricular endocardial cushion Present Regionally restricted 6B DKO Immunostaining showed dysregulated deposition of collagen I.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory