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Gene Expression Data
Assay Details
Assay
Reference: J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7666627
Gene symbol: Crk
Gene name: v-crk avian sarcoma virus CT10 oncogene homolog
Results
Specimen 1A Control: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS19: heart Present Ubiquitous 1A Control
Specimen 1A DKO center: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Weak Regionally restricted 1A DKO center Reduced expression was observed in the mesenchymal atrioventricular cushions in the DKO embryos.
Specimen 1A DKO right: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant. Double labeled: red - Crk; green - R26fsGFP/+.
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Weak Regionally restricted 1A DKO right Reduced expression was observed in the mesenchymal atrioventricular cushions in the DKO embryos.
Specimen 1B Control: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Structure Level Pattern Image Note
TS19: heart Present Ubiquitous 1B Control
Specimen 1B DKO center: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: outflow tract Weak Regionally restricted 1B DKO center Reduced expression was observed in the proximal outflow tract derived from the endocardial cells in DKO embryos.
Specimen 1B DKO right: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant. Double labeled: red - Crk; green - R26fsGFP/+.
Structure Level Pattern Image Note
TS19: outflow tract Weak Regionally restricted 1B DKO right Reduced expression was observed in the proximal outflow tract derived from the endocardial cells in DKO embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory