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Gene Expression Data
Assay Details
Assay
Reference: J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
Assay type: RNA in situ
MGI Accession ID: MGI:7666621
Gene symbol: Crkl
Gene name: v-crk avian sarcoma virus CT10 oncogene homolog-like
Probe: Mm-Crkl (514681)
Probe preparation: Antisense RNA
Visualized with: Fluorescence
Results
Specimen 1C control: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur (more )
Note: Double labeled: red - Crkl; green - Cdh5 (assay MGI:7666620).
Structure Level Pattern Image Note
TS19: heart Present Ubiquitous 1C Control
Specimen 1C DKO: embryonic day 11.5; Crktm1Cur/Crktm1Cur, Crkltm1Cur/Crkltm1Cur, Nfatc1tm1.1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant. Double labeled: red - Crkl; green - Cdh5 (assay MGI:7666620).
Structure Level Pattern Image Note
TS19: atrioventricular endocardial cushion Weak Regionally restricted 1C DKO Reduced expression was observed in the mesenchymal atrioventricular cushions in the DKO embryos.
TS19: outflow tract Weak Regionally restricted 1C DKO Reduced expression was observed in the proximal outflow tract derived from the endocardial cells in DKO embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory