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Gene Expression Data
Assay Details
Assay
Reference: J:344641 Raju R, et al., Profiles of Wnt pathway gene expression during tooth morphogenesis. Front Physiol. 2023;14:1316635
Assay type: RNA in situ
MGI Accession ID: MGI:7646918
Gene symbol: Wnt10a
Gene name: wingless-type MMTV integration site family, member 10A
Probe: Mm-Wnt10a (401061)
Probe preparation: Antisense DNA
Visualized with: Fluorescence
Results
Specimen 1A1: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw molar epithelium Present Regionally restricted 1A1 Expression throughout molar bud epithelium. Stronger expression towards buccal side of dental epithelium.
TS21: enamel knot Strong 1A1 Strongest expression in enamel knot.
Specimen 1B1: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: upper jaw molar epithelium Present Regionally restricted 1B1 Expression in palatal/lingual region of dental eptitheium, along with stronger expression in buccal dental epithelium.
TS23: upper jaw molar mesenchyme Present Regionally restricted 1B1 Expression shifting to surrounding mesenchymal cells adjacent to enamel knot.
TS23: enamel knot Present Diffuse 1B1 Diffuse expression pattern within enamel knot region.
Specimen 2A1: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: upper jaw molar epithelium Strong Regionally restricted 2A1 Expression strongly localized to inner dental epithelium.
TS26: upper jaw molar odontoblast Present Regionally restricted 2A1 Expression in terminally-differentiating odontoblasts corresponding to future developing cusps.
Specimen 2B1: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: upper jaw molar ameloblast Strong Regionally restricted 2B1 Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
TS27: upper jaw molar odontoblast Strong Regionally restricted 2B1 Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
Specimen 2C1: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw molar odontoblast Present Regionally restricted 2C1 Expression primarily localized to odontoblasts.
TS28: upper jaw molar epithelium Weak Regionally restricted 2C1 Weaker expression in reduced dental epithelium (RDE).
TS28: Hertwig's epithelial root sheath Strong 2C1 Strong expression in elongated Hertwig's epithelial root sheath (HERS).
Specimen 2D: postnatal day 0 (more )
Note: Triple labeled: yellow - Wnt10a; magenta - Dkk1 (assay MGI:7646972); green - Sost (assay MGI:7646971).
Structure Level Pattern Image Note
TS27: lower jaw molar Present 2D
Specimen 2E: postnatal day 0 (more )
Note: Triple labeled: yellow - Wnt10a; magenta - Dkk1 (assay MGI:7646972); green - Sost (assay MGI:7646971).
Structure Level Pattern Image Note
TS27: upper jaw incisor Present 2E
Specimen 2F: postnatal day 0 (more )
Note: Triple labeled: yellow - Wnt10a; magenta - Dkk1 (assay MGI:7646972); green - Sost (assay MGI:7646971).
Structure Level Pattern Image Note
TS27: lower jaw incisor Present 2F
Specimen 3A1,A2: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw incisor ameloblast Strong Regionally restricted 3A2 , 3A1 Intense expression in ameloblasts and odontoblasts towards proximal end near cervical loop.
TS28: upper jaw incisor odontoblast Strong Regionally restricted 3A2 , 3A1 Intense expression in ameloblasts and odontoblasts towards proximal end near cervical loop.
Specimen 3B1,B2: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: upper jaw incisor Strong Regionally restricted 3B1 , 3B2 Intense expression in ameloblasts and odontoblasts towards proximal end near cervical loop.
Specimen S1 Maxillary Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present S1_maxillary E12.5 Wnt10a
TS20: jaw primordium epithelium Present Regionally restricted S1_maxillary E12.5 Wnt10a Expression in presumptive dental epithelium.
TS20: jaw primordium mesenchyme Absent S1_maxillary E12.5 Wnt10a
Specimen S1 Maxillary Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: enamel knot Present Regionally restricted S1_maxillary E14.5 Wnt10a Expression exclusively in enamel knot area, slightly stronger along buccal side.
Specimen S1 Maxillary Molar E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: upper jaw molar epithelium Strong Regionally restricted S1_maxillary E17.5 Wnt10a Expression strongly localized to inner dental epithelium.
TS25: upper jaw molar odontoblast Present Regionally restricted S1_maxillary E17.5 Wnt10a Expression in terminally-differentiating odontoblasts corresponding to future developing cusps.
Specimen S1 Mandibular Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present S1_mandibular E12.5 Wnt10a
TS20: jaw primordium epithelium Present Regionally restricted S1_mandibular E12.5 Wnt10a Expression in presumptive dental epithelium.
TS20: jaw primordium mesenchyme Absent S1_mandibular E12.5 Wnt10a
Specimen S1 Mandibular Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw molar epithelium Present Regionally restricted S1_mandibular E14.5 Wnt01a Expression exclusively in enamel knot area, slightly stronger alon buccal side.
Specimen S1 Mandibular Molar E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lower jaw molar ameloblast Present Regionally restricted S1_mandibular E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip regions.
TS25: lower jaw molar odontoblast Present Regionally restricted S1_mandibular E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip regions.
Specimen S2 Maxillary Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present S2_maxillary E12.5 Wnt10a
TS20: jaw primordium epithelium Present Regionally restricted S2_maxillary E12.5 Wnt10a Authors report similar expression patterns in incisors as seen for molars. Expression in presumptive dental epithelium.
TS20: jaw primordium mesenchyme Absent S2_maxillary E12.5 Wnt10a
Specimen S2 Maxillary Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw incisor epithelium Strong Regionally restricted S2_maxillary E13.5 Wnt10a Strong expression along labial border of epithelial invagination.
Specimen S2 Maxillary Incisor E15.5: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: upper jaw incisor ameloblast Present Regionally restricted S2_maxillary E15.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
TS23: upper jaw incisor odontoblast Present Regionally restricted S2_maxillary E15.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
Specimen S2 Maxillary Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lower jaw incisor ameloblast Present Regionally restricted S2_maxillary E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
TS25: lower jaw incisor odontoblast Present Regionally restricted S2_maxillary E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
Specimen S2 Mandibular Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral epithelium Present S2_mandibular E12.5 Wnt10a
TS20: jaw primordium epithelium Present Regionally restricted S2_mandibular E12.5 Wnt10a Authors report similar expression patterns in incisors as seen for molars. Expression in presumptive dental epithelium.
TS20: jaw primordium mesenchyme Absent S2_mandibular E12.5 Wnt10a
Specimen S2 Mandibular Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Strong Regionally restricted S2_mandibular E13.5 Wnt10a Strong expression along labial border of epithelial invagination.
Specimen S2 Mandibular Incisor E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw incisor Present S2_mandibular E15.5 Wnt10a
Specimen S2 Mandibular Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lower jaw incisor ameloblast Present Regionally restricted S2_mandibular E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
TS25: lower jaw incisor odontoblast Present Regionally restricted S2_mandibular E17.5 Wnt10a Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip.
Specimen S3B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Strong Regionally restricted S3B Expression throughout molar bud epithelium, with strongest expression in enamel knot. Stronger expression towards buccal side of dental epithelium.
Specimen S3F: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw molar mesenchyme Present Regionally restricted S3F Expression shifting to surrounding mesenchymal cells adjacent to enamel knot.
TS23: enamel knot Present Diffuse S3F Diffuse expression pattern within enamel knot region.
TS23: lower jaw molar epithelium Present Regionally restricted S3F Expression in palatal/lingual region of dental eptitheium, along with stronger expression in buccal dental epithelium.
Specimen S4B: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: lower jaw molar ameloblast Present Graded S4B Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip
TS26: lower jaw molar odontoblast Present Graded S4B Expression corresponded to gradient of terminally differentiating ameloblasts and odontoblasts at cusp tip
Specimen S4F: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar ameloblast Weak Regionally restricted S4F Weaker expression in ameloblasts and odontoblasts located at occlusal groove.
TS27: lower jaw molar odontoblast Weak Regionally restricted S4F Weaker expression in ameloblasts and odontoblasts located at occlusal groove.
Specimen S4J: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: lower jaw molar odontoblast Present S4J Expression primarily localized to odontoblasts.
TS28: lower jaw molar epithelium Weak Regionally restricted S4J Weaker expression in reduced dental epithelium (RDE).
TS28: Hertwig's epithelial root sheath Strong S4J Strong expression in elongated Hertwig's epithelial root sheath (HERS).
Specimen S5A E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: upper jaw molar Present S5A E16.5 Wnt10a
Specimen S5A E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: upper jaw molar Present S5A E17.5 Wnt10a
Specimen S5A P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: upper jaw incisor Present S5A P0 Wnt10a
Specimen S5B E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lower jaw molar Present S5B E16.5 Wnt10a
Specimen S5B E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lower jaw molar Present S5B E17.5 Wnt10a
Specimen S5B P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: lower jaw molar Present S5B P0 Wnot10a
Specimen S6 Maxillary Incisor: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: upper jaw incisor ameloblast Strong Regionally restricted S6_maxillary Wnt10a Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
TS27: upper jaw incisor odontoblast Strong Regionally restricted S6_maxillary Wnt10a Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
Specimen S6 Mandibular Incisor: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw incisor ameloblast Strong Regionally restricted S6_mandibular Wnt10a Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
TS27: lower jaw incisor odontoblast Strong Regionally restricted S6_mandibular Wnt10a Intense expression in terminally differentiated ameloblasts and odontoblasts along developing cusp tip.
Specimen S6 Maxillary Molar: postnatal day 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw molar odontoblast Weak S7_maxillary Wnt10a
Specimen S6 Mandibular Molar: postnatal day 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: lower jaw molar odontoblast Weak S7_mandibular Wnt10a
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory