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Gene Expression Data
Assay Details
Assay
Reference: J:312371 Da Silva F, et al., Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021 Oct 1;40(19):e108041
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643253
Gene symbol: Lrp6
Gene name: low density lipoprotein receptor-related protein 6
Antibody: Phospho-LRP6 (Ser1490) Antibody #2568
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen Ev1 I: embryonic day 13.5; Ccnytm1.1Smoc/Ccny+, Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1+ (more )
Structure Cell Type Level Pattern Image Note
TS21: cerebral cortex ventricular layer neural progenitor cell Present Regionally restricted EV1_I left , EV1_I right Concentrated at the apical cell cortex/apical plasma membrane, in 90% of mitotic apical progenitors analyzed.
TS21: cerebral cortex subventricular zone neural progenitor cell Present EV1_I left Observed in 88% of mitotic basal progenitors.
Specimen Ev5 C: embryonic day 12.5 (more )
Note: Double labeled: green - Lrp6; red - Sox4 (assay MGI:7643254).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present EV5_C right Coexpressed with Sox4 in mitotic basal progenitors.
Specimen Ev5 N: embryonic day 12.5 (more )
Note: Double labeled: green - Lrp6; red - Sox11 (assay MGI:7643260).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex subventricular zone neural progenitor cell Present EV5_N right Coexpressed with Sox11 in mitotic basal progenitors.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory