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Gene Expression Data
Assay Details
Assay
Reference: J:192361 Srinivasan K, et al., A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7620291
Gene symbol: Bhlhe22
Gene name: basic helix-loop-helix family, member e22
Antibody: Anti-Bhlhb5
Results
Specimen 4A: postnatal day 4 (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Strong 4A
TS28: cortical layer II cerebral cortex neuron Moderate 4A Expression level was moderate to low in upper layers.
TS28: cortical layer III cerebral cortex neuron Moderate 4A Expression level was moderate to low in upper layers.
TS28: cortical layer IV cerebral cortex neuron Moderate 4A Expression level was moderate to low in upper layers.
Specimen 4B: postnatal day 4; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Weak 4B Expression was significantly reduced in the conditional mutant.
Specimen 4C: postnatal day 4; Fezf2tm1Skm/Fezf2tm1Skm (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Weak 4C Expression was decreased in both layers 5 and 6 in the mutant.
TS28: cortical layer VI cerebral cortex neuron Weak 4C Expression was decreased in both layers 5 and 6 in the mutant.
Specimen 4D: postnatal day 4; Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Present 4D Expression in layer 5 was rescued in the double mutant.
Specimen 4E: postnatal day 4; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2+ (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer II cerebral cortex neuron Strong 4E Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer III cerebral cortex neuron Strong 4E Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer IV cerebral cortex neuron Strong 4E Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer V cerebral cortex neuron Strong 4E Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer VI cerebral cortex neuron Strong 4E Expression was increased in both layer 5 and the upper layers.
Specimen 4F: postnatal day 4; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer II cerebral cortex neuron Strong 4F Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer III cerebral cortex neuron Strong 4F Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer IV cerebral cortex neuron Strong 4F Expression was increased in both layer 5 and the upper layers.
TS28: cortical layer V cerebral cortex neuron Strong 4F Expression was increased in both layer 5 and the upper layers.
Specimen 5A: postnatal day 4; Satb2tm1Rug/Satb2tm2Rug (more )
Note: Double labeled: red - Bhlhe22; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Strong 5A
Specimen 5B: postnatal day 4; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm1Rug (more )
Note: Conditional mutant. Double labeled: red - Bhlhe22; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS28: neocortex layer cerebral cortex neuron Present Regionally restricted 5B Expression was increased in the upper layers.
Specimen 5C: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk (more )
Note: Double labeled: red - Bhlhe22; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS27: neocortex layer cerebral cortex neuron Present Regionally restricted 5C Expression was increased in the upper layers.
Specimen 5D: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Bhlhe22; green - Tbr1 (assay MGI:7620298).
Structure Cell Type Level Pattern Image Note
TS27: neocortex layer cerebral cortex neuron Present Regionally restricted 5D Expression was increased in the upper layers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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