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Gene Expression Data
Assay Details
Assay
Reference: J:249381 Yang AW, et al., Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice. Neurogenetics. 2015 Oct;16(4):277-85
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7616313
Gene symbol: Calb1
Gene name: calbindin 1
Antibody: anti-CALB
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3A: postnatal day 20 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Uniform 3A
Specimen 3A inset: postnatal day 20 (more )
Note: Double labeled: green - Calb1; red - Gfap (assay MGI:7616314).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Uniform 3A inset Expression in uniform monolayer of Purkinje cells.
Specimen 3B: postnatal day 20; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3B Only a few areas of Purkinje cell loss were prominent, most notably in lobes 8 and 11.
Specimen 3B inset: postnatal day 20; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Note: Double labeled: green - Calb1; red - Gfap (assay MGI:7616314).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3B inset Authors report area of Purkinje cell loss.
Specimen 3C: postnatal day 45; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3C Progressive Purkinje cell loss affecting other lobes.
Specimen 3C inset: postnatal day 45; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Note: Double labeled: green - Calb1; red - Gfap (assay MGI:7616314).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3C inset Progressive Purkinje cell loss affecting other lobes.
Specimen 3D: postnatal day 60; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3D Progressive Purkinje cell loss affecting other lobes.
Specimen 3D inset: postnatal day 60; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Note: Double labeled: green - Calb1; red - Gfap (assay MGI:7616314).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 3D inset Progressive Purkinje cell loss affecting other lobes.
Specimen 4A: postnatal day 60 (more )
Note: Double labeled: green - Calb1; red - Slc17a6 (assay MGI:7616315).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 4A
Specimen 4B: postnatal day 60; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Note: Double labeled: green - Calb1; red - Slc17a6 (assay MGI:7616315).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 4B Large areas of Purkinje cell degenerataion and gliosis. Surviving cells maintain normal molecular layer morphology.
Specimen 4C: postnatal day 20 (more )
Note: Double labeled: green - Calb1; red - Inpp5e (assay MGI:7616316).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 4C
Specimen 4D: postnatal day 20; Inpp5aGt(OST50073)Lex/Inpp5aGt(OST50073)Lex (more )
Note: Double labeled: green - Calb1; red - Inpp5e (assay MGI:7616316).
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 4D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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