Lrrn4 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:201549 Bando T, et al., Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Neurosci Lett. 2013 Aug 26;548:73-8
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:7614987
Gene symbol:	Lrrn4
Gene name:	leucine rich repeat neuronal 4

Reporter:	lacZ
	Direct Detection

Results

Specimen not shown: embryonic day 12.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Level	Pattern	Image	Note
TS20: dorsal root ganglion	Absent

Specimen 2A: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Punctate	2A	Punctate expression in some neurons.

Specimen 2B: embryonic day 15.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS23: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		2B

Specimen 2C: embryonic day 17.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS25: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	2C	Number of expressing neurons increased.

Specimen 2D: postnatal day 0; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		2D

Specimen 2E: postnatal day 7; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	2E	No significant change in percentage of expressing neurons between E17.5 and P7.

Specimen 2F: postnatal day 14; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	2F	Percentage of expressing neurons decreased at P14.

Specimen 2G: postnatal adult; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		2G	Percentage of expressing neurons decreased at P14.

Specimen S1A: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		S1A

Specimen S1B: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		S1B

Specimen S1C: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		S1C

Specimen S1D: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		S1D

Specimen 3A: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3A

Specimen 3B: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3B

Specimen 3C: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3C	Expression predominantly in Ntrk3-expressing neurons, compared with Ntrk1-, Ntrk2- and Ret-expressing neurons.

Specimen 3D: embryonic day 13.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS21: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3D

Specimen 3E: embryonic day 15.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS23: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3E

Specimen 3F: embryonic day 15.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS23: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3F

Specimen 3G: embryonic day 15.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS23: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3G	Prevalence expression in Ntrk3-expressing neurons decreased.

Specimen 3H: embryonic day 15.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS23: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3H

Specimen 3I: embryonic day 17.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS25: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3I	Predominant expression in Ntrk1-expressing neurons.

Specimen 3J: embryonic day 17.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS25: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3J

Specimen 3K: embryonic day 17.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS25: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3K

Specimen 3L: embryonic day 17.5; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS25: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3L

Specimen 3M: postnatal day 0; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS27: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3M	Predominant expression in Ntrk1-expressing neurons.

Specimen 3N: postnatal day 0; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS27: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3N

Specimen 3O: postnatal day 0; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS27: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3O

Specimen 3P: postnatal day 0; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS27: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3P

Specimen 3Q: postnatal day 7; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3Q	Expression predominantly in Ntrk1- and Ret-expressing neurons.

Specimen 3R: postnatal day 7; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3R	Expression in some Ntrk2-expressing neurons.

Specimen 3S: postnatal day 7; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3S	Expression in some Ntrk3-expressing neurons.

Specimen 3T: postnatal day 7; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3T	Expression predominantly in Ntrk1- and Ret-expressing neurons.

Specimen 3U: postnatal day 14; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk1 (assay MGI:7615049).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3U	Expression exclusively in Ntrk1- and Ret-expressing neurons.

Specimen 3V: postnatal day 14; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk2 (assay MGI:7615050).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3V

Specimen 3W: postnatal day 14; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ntrk3 (assay MGI:7615051).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		3W

Specimen 3X: postnatal day 14; Lrrn4^tm1Ami/Lrrn4^tm1Ami (more

)
Note: Double labeled: blue - Lrrn4 reporter; brown - Ret (assay MGI:7615052).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present	Regionally restricted	3X	Expression exclusively in Ntrk1- and Ret-expressing neurons.

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