Cdkn2a In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:149526 Freeman-Anderson NE, et al., Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development. Development. 2009 Jun;136(12):2081-9
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:7610021
Gene symbol:	Cdkn2a
Gene name:	cyclin dependent kinase inhibitor 2A

Reporter:	GFP
Antibody:	anti-GFP (#A-6455)

Results

4Bb ©

Specimen 4Bb: embryonic day 15.5; Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs, Tgfb2^tm1Doe/Tgfb2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: vitreous humour	Present	Regionally restricted	4Bb	Nearly all the hyperplastic vitreous cells were immunolabeled for the GFP reporter.

4Bd ©

Specimen 4Bd: embryonic day 15.5; Cdkn2a^tm1(GFP)Cjs/Cdkn2a^tm1(GFP)Cjs, Tgfb2^tm1Doe/Tgfb2^tm1Doe (more

)

Structure	Level	Pattern	Image	Note
TS23: vitreous humour	Weak		4Bd	GFP staining was markedly decreased in the Tgfb2<-/->;Arf<GFP/GFP> hyperplastic vitreous cells.

4Da ©

Specimen 4Da: embryonic day 13.5; Cdkn2a^tm1(GFP)Cjs/Cdkn2a⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: vitreous humour	Present		4Da	Staining in an adjacent section indicated that some Cdkn2a-expressing cells also express Tgfbr2.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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