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Gene Expression Data
Assay Details
Assay
Reference: J:149526 Freeman-Anderson NE, et al., Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development. Development. 2009 Jun;136(12):2081-9
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7610019
Gene symbol: Cdkn2a
Gene name: cyclin dependent kinase inhibitor 2A
Reporter: lacZ
Direct Detection
Results
Specimen 2C ArflacZ/+: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: eye Present 2C ArflacZ/+
Specimen 2C ArflacZ/lacZ: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2atm1Sxs (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: eye Present Widespread 2C ArflacZ/lacZ Expression was greatly expanded in the Arf<lacZ/lacZ> embryo.
Specimen 4Ca: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+, Tgfb2tm1Doe/Tgfb2+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: vitreous humour Present 4Ca
Specimen 4Cb: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+, Tgfb2tm1Doe/Tgfb2tm1Doe (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: vitreous humour Weak 4Cb Staining was markedly decreased in the Tgfb2<-/->;Arf<lacZ/+> hyperplastic vitreous cells.
Specimen 5Aa: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: cornea stroma Present 5Aa
Specimen 5Ac: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: cornea stroma Present 5Ac
Specimen 5Ad: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+, Tgfb2tm1Doe/Tgfb2tm1Doe (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: cornea stroma Weak 5Ad
Specimen 5Cb: embryonic day 14.5; Cdkn2atm1Sxs/Cdkn2atm1Sxs (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS22: left umbilical artery Present 5Cb
TS22: right umbilical artery Present 5Cb
Specimen 5Cc: embryonic day 14.5; Cdkn2atm1Sxs/Cdkn2atm1Sxs (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Cell Type Level Pattern Image Note
TS22: umbilical artery embryonic part perivascular cell Present 5Cc
TS22: umbilical artery embryonic part umbilical artery endothelial cell Absent 5Cc
Specimen 5Da: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+, Tgfb2tm1Doe/Tgfb2+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: left umbilical artery Present 5Da
TS21: right umbilical artery Present 5Da
Specimen 5Db: embryonic day 13.5; Cdkn2atm1Sxs/Cdkn2a+, Tgfb2tm1Doe/Tgfb2tm1Doe (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS21: left umbilical artery Weak 5Db
TS21: right umbilical artery Weak 5Db
Specimen S6Aa ArflacZ/lacZ: postnatal; Cdkn2atm1Sxs/Cdkn2atm1Sxs (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS28: testis Present s6Aa ArflacZ/lacZ
Specimen S6Ac: postnatal; Cdkn2atm1Sxs/Cdkn2atm1Sxs (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Level Pattern Image Note
TS28: testis Present s6Ac ArflacZ/lacZ
Specimen S6B: postnatal newborn; Cdkn2atm1Sxs/Cdkn2a+ (more )
Note: Fix: 1% formaldehyde, 0.2% glutaraldehyde
Structure Cell Type Level Pattern Image Note
TS27: hyaloid vascular plexus perivascular cell Present s6B right , s6B left
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory