About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:286599 Song NN, et al., Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
Assay type: RNA in situ
MGI Accession ID: MGI:7608312
Gene symbol: Rnf220
Gene name: ring finger protein 220
Results
Specimen 3A Rnf220 E2: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 3A Rnf220 E2 Expression in dorsal rhombomere 1, overlapping with Dbh expression.
Specimen 3B Rnf220 E2: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pons Present Regionally restricted 3B Rnf220 E2 Expression overlapping with Dbh expression.
Specimen 3C Rnf220 E2: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Strong 3C Rnf220 E2 Strong expression in locus coeruleus, identical to that of Zc4h2 expression.
TS24: pons Strong Regionally restricted 3C Rnf220 E2 Strong expression in Barrington's nucleus, identical to that of Zc4h2 expression.
Specimen 3D Rnf220 E2 Control: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Present 3D Control
Specimen 3D Rnf220 E2 Rnf220 KO: embryonic day 16.5; Rnf220em1.1Kust/Rnf220em1.1Kust (more )
Structure Level Pattern Image Note
TS24: hindbrain Absent 3D KO Successful deletion confirmed.
Specimen S1D: embryonic day 11.5 (more )
Note: Double labeled: blue - Rnf220; brown - Zc4h2 (assay MGI:7608331).
Structure Cell Type Level Pattern Image Note
TS19: metencephalon basal plate mantle layer noradrenergic neuron Present Regionally restricted S1D Expression colocalized with Rnf220 expression in locus coeruleus noradrenergic neurons.
Specimen S3A, inset: embryonic day 12.5 (more )
Note: Double labeled: blue - Rnf220; brown - Th (assay MGI:7610009).
Structure Level Pattern Image Note
TS20: sympathetic ganglion Absent S3A , S3A inset
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory