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Gene Expression Data
Assay Details
Assay
Reference: J:286599 Song NN, et al., Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
Assay type: RNA in situ
MGI Accession ID: MGI:7608312
Gene symbol: Rnf220
Gene name: ring finger protein 220
Results
Specimen 3A Rnf220 E2: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 3A Rnf220 E2 Expression in dorsal rhombomere 1, overlapping with Dbh expression.
Specimen 3B Rnf220 E2: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pons Present Regionally restricted 3B Rnf220 E2 Expression overlapping with Dbh expression.
Specimen 3C Rnf220 E2: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Strong 3C Rnf220 E2 Strong expression in locus coeruleus, identical to that of Zc4h2 expression.
TS24: pons Strong Regionally restricted 3C Rnf220 E2 Strong expression in Barrington's nucleus, identical to that of Zc4h2 expression.
Specimen 3D Rnf220 E2 Control: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Present 3D Control
Specimen 3D Rnf220 E2 Rnf220 KO: embryonic day 16.5; Rnf220em1.1Kust/Rnf220em1.1Kust (more )
Structure Level Pattern Image Note
TS24: hindbrain Absent 3D KO Successful deletion confirmed.
Specimen S1D: embryonic day 11.5 (more )
Note: Double labeled: blue - Rnf220; brown - Zc4h2 (assay MGI:7608331).
Structure Cell Type Level Pattern Image Note
TS19: metencephalon basal plate mantle layer noradrenergic neuron Present Regionally restricted S1D Expression colocalized with Rnf220 expression in locus coeruleus noradrenergic neurons.
Specimen S3A, inset: embryonic day 12.5 (more )
Note: Double labeled: blue - Rnf220; brown - Th (assay MGI:7610009).
Structure Level Pattern Image Note
TS20: sympathetic ganglion Absent S3A , S3A inset
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory