About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:293624 Lee S, et al., Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk. Development. 2020 Apr 30;147(21):dev187369
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7607119
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved caspase-3 (Asp175) (5A1E; #9664)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 2B Wildtype E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: latero-nasal process Present Regionally restricted 2B Wildtype E10.5 Expression was detected in the epithelial seam at the fusion site between medial nasal process and lateral nasal process.
TS17: medial-nasal process Present Regionally restricted 2B Wildtype E10.5 Expression was detected in the epithelial seam at the fusion site between medial nasal process and lateral nasal process.
Specimen 2B Esrp1-/- E10.5: embryonic day 10.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS17: latero-nasal process Trace 2B Esrp1-/- E10.5 Medial and lateral nasal process in the mutant embryos did not reveal substantial apoptosis.
TS17: medial-nasal process Trace 2B Esrp1-/- E10.5 Medial and lateral nasal process in the mutant embryos did not reveal substantial apoptosis.
Specimen 2B Wildtype E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: latero-nasal process Present Regionally restricted 2B Wildtype E11.5 Expression was detected in the epithelial seam at the fusion site between medial nasal process and lateral nasal process.
TS19: medial-nasal process Present Regionally restricted 2B Wildtype E11.5 Expression was detected in the epithelial seam at the fusion site between medial nasal process and lateral nasal process.
Specimen 2B Esrp1-/- E11.5: embryonic day 11.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS19: latero-nasal process Trace 2B Esrp1-/- E11.5 Medial and lateral nasal process in the mutant embryos did not reveal substantial apoptosis.
TS19: medial-nasal process Trace 2B Esrp1-/- E11.5 Medial and lateral nasal process in the mutant embryos did not reveal substantial apoptosis.
Specimen 3A Wildtype: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: secondary palate Present Regionally restricted 3A Wildtype middle Apoptosis was detected at the site of fusion.
Specimen 3A Esrp1-/-: embryonic day 16.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS24: secondary palate Ambiguous 3A Esrp1-/- middle No increase in apoptosis was evident in the mutant embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory