Pecam1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:283328 Klimovich B, et al., Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2020 Jan;19(1):109-123
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7569303
Gene symbol:	Pecam1
Gene name:	platelet/endothelial cell adhesion molecule 1

Antibody:	MEC 13.3
Detection system:	Secondary antibody coupled to horseradish peroxidase

Results

Specimen 2e Mdm2+/-: embryonic day 11.5; Mdm2^tm1.1Mep/Mdm2⁺, Trp53^tm1.1Thst/Trp53^tm1.1Thst (more

)

Structure	Level	Pattern	Image	Note
TS19: yolk sac blood vessel	Present		2e Mdm2+/-;Trp53RR/RR (inset) , 2e Mdm2+/-;Trp53RR/RR

Specimen 2e Mdm2-/-: embryonic day 11.5; Mdm2^tm1.1Mep/Mdm2^tm1.1Mep, Trp53^tm1.1Thst/Trp53^tm1.1Thst (more

)

Structure	Level	Pattern	Image	Note
TS19: yolk sac blood vessel	Present	Regionally restricted	2e Mdm2-/-;Trp53RR/RR , 2e Mdm2-/-;Trp53RR/RR (inset)	Clearly reduced number of large blood vessels and decreased branching of capillary network compared to control.

Specimen 2f Mdm2+/-: embryonic day 11.5; Mdm2^tm1.1Mep/Mdm2⁺, Trp53^tm1.1Thst/Trp53^tm1.1Thst (more

)

Structure	Level	Pattern	Image	Note
TS19: blood vessel	Present		2f Mdm2+/-;Trp53RR/RR

Specimen 2f Mdm2-/-: embryonic day 11.5; Mdm2^tm1.1Mep/Mdm2^tm1.1Mep, Trp53^tm1.1Thst/Trp53^tm1.1Thst (more

)

Structure	Level	Pattern	Image	Note
TS19: blood vessel	Present	Regionally restricted	2f Mdm2-/-;Trp53RR/RR	Authors report reduced branching in blood vessel network compared to control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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