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Gene Expression Data
Assay Details
Assay
Reference: J:225226 Dykes IM, et al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7569156
Gene symbol: Hic2
Gene name: hypermethylated in cancer 2
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 7.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS11: amnion Present 2A Before heart tube formation, expression in amnion and chorion.
TS11: chorion Present 2A Before heart tube formation, expression in amnion and chorion.

Specimen 2B: embryonic day 8.0; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS12: primitive heart tube Present 2B At linear heart tube stage, expresson spcific to heart and venous limbs.
TS12: sinus venosus Present 2B At linear heart tube stage, expresson spcific to heart and venous limbs.

Specimen 2C: embryonic day 8.0; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS12: primitive heart tube Present 2C At linear heart tube stage, expresson spcific to heart and venous limbs.
TS12: sinus venosus Present 2C At linear heart tube stage, expresson spcific to heart and venous limbs.

Specimen 2D: embryonic day 8.0; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS12: primitive heart tube Present 2D
TS12: gut Absent 2D
TS12: neural plate Absent 2D

Specimen 2E: embryonic day 8.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS13: heart Present 2E As heart begins to loop, expession remains specific to heart and venous limbs.
TS13: sinus venosus Present 2E As heart begins to loop, expession remains specific to heart and venous limbs.

Specimen 2F: embryonic day 8.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS13: primitive ventricle Present 2F Expression in both future ventricles.

Specimen 2G: embryonic day 9.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS15: heart Present 2G In looped heart, expression remains confined to heart.

Specimen 2H: embryonic day 9.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS15: heart atrium Present 2H Expression in all cardiac chambers and in outflow tract.
TS15: outflow tract Present 2H Expression in all cardiac chambers and in outflow tract.
TS15: primitive ventricle Present 2H Expression in all cardiac chambers and in outflow tract.

Specimen 2I,J: embryonic day 10.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS17: heart Present 2J , 2I
TS17: future spinal cord Present Regionally restricted 2I , 2J Expression in ventral part of spinal cord.

Specimen 2K: embryonic day 10.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS17: heart atrium Present Regionally restricted 2K Expression in right ventricle, left ventricle, right atrium and outflow tract.
TS17: outflow tract Present Regionally restricted 2K Expression in right ventricle, left ventricle, right atrium and outflow tract.
TS17: primitive ventricle Present Regionally restricted 2K Expression in right ventricle, left ventricle, right atrium and outflow tract.

Specimen 2L,M,N: embryonic day 11.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS19: midbrain Weak 2N , 2M , 2L Low level of expression in midbrain.
TS19: future spinal cord Present 2L , 2N , 2M Expression persists in heart and spinal cord.
TS19: heart Present 2L , 2N , 2M Expression persists in heart and spinal cord.

Specimen 3E: embryonic day 15.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS23: cardiac muscle tissue Present Widespread 3E Expression throughout myocardium.

Specimen 3F: embryonic day 15.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Structure Level Pattern Image Note
TS23: cardiac muscle tissue Present 3F

Specimen 3G: embryonic day 15.5; Hic2Gt(RRN127)Byg/Hic2+ (more )
Note: ,
Structure Level Pattern Image Note
TS23: cardiac muscle tissue Present 3G


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory