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Gene Expression Data
Assay Details
Assay
Reference: J:240101 Lv J, et al., 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7549045
Gene symbol: Mapk1
Gene name: mitogen-activated protein kinase 1
Antibody: anti-ERK
Detection system: fluorescein
Results
Specimen 7F tph2+/+: embryonic day 10.5 (more )
Note: Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Present 7F tph2+/+
Specimen 7F tph2+/-: embryonic day 10.5; Tph2tm1.1Zfc/Tph2+ (more )
Note: Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Present 7F tph2+/-
Specimen 7F tph2-/-: embryonic day 10.5; Tph2tm1.1Zfc/Tph2tm1.1Zfc (more )
Note: Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Strong 7F tph2-/- Expression increased compared to control.
Specimen 7F pet1-cre; tph2+/+: embryonic day 10.5; Tg(Fev-cre)1Esd/0 (more )
Note: Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Present 7F pet1-cre; tph2+/+
Specimen 7F pet1-cre; tph2+/fl: embryonic day 10.5; Tg(Fev-cre)1Esd/0, Tph2tm1.1Kpl/Tph2+ (more )
Note: Conditional mutant. Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Present 7F pet-cre; tph2+/fl
Specimen 7F pet1-cre; tph2fl/fl: embryonic day 10.5; Tg(Fev-cre)1Esd/0, Tph2tm1.1Kpl/Tph2tm1.1Kpl (more )
Note: Conditional mutant. Double labeled: green - Mapk1 and Mapk3; red - phospho-histone H3.
Structure Level Pattern Image Note
TS17: aorta-gonad-mesonephros Strong 7F pet-cre; tph2fl/fl Expression increased compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory