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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548377
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Antibody: anti-CTIP2 [25B6] (ab18465)
Detection system: Secondary antibody
Results
Specimen 5C CTIP2 WT: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex neuron Present 5C WT Expression in early born neurons.
Specimen 5C CTIP2 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 5C Trp53 cKO Expression not altered compared to wild type.
Specimen 5C CTIP2 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Weak 5C BubR1 cKO Expression signficantly reduced compared to wild type.
Specimen 5C CTIP2 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Weak 5C dcKO Expression not altered at all compared to BubR1 cKO.
Specimen 7E CTIP2 WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex neuron Present 7E WT Expression in early born neurons.
Specimen 7E CTIP2 Trp53 cKO: postnatal day 21; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Present 7E Trp53 cKO Expression not altered compared to wild type.
Specimen 7E CTIP2 BubR1 cKO: postnatal day 21; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Weak 7E Bub/r1 cKO Expression signficantly reduced compared to wild type.
Specimen 7E CTIP2 dcKO: postnatal day 21; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebral cortex Weak 7E dcKO Loss of expression not mproved compared to BubR1 cKO.
Specimen 8C CTIP2 WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: hippocampus neuron Present 8C WT Expression in early born neurons.
Specimen 8C CTIP2 Trp53 cKO: postnatal day 21; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus Present 8C Trp53 cKO Expression not altered compared to wild type.
Specimen 8C CTIP2 BubR1 cKO: postnatal day 21; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus Weak 8C BubR1 cKO Expression significantly reduced compared to wild type.
Specimen 8C CTIP2 dcKO: postnatal day 21; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus Weak 8C dcKO Loss of expression not improved compared to BubR1 cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory