Eomes Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7548376
Gene symbol:	Eomes
Gene name:	eomesodermin

Antibody:	anti-Eomes/Tbr2 (ab23345)
Detection system:	Secondary antibody

Results

5A WT ©

Specimen 5A TBR2 WT: embryonic day 14.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS22: cerebral cortex	neural progenitor cell	Present		5A WT

5A Trp53 cKO ©

Specimen 5A TBR2 Trp53 cKO: embryonic day 14.5; Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: cerebral cortex	Present		5A Trp53 cKO

5A BubR1 cKO ©

Specimen 5A TBR2 BubR1 cKO: embryonic day 14.5; Bub1b^tm1Jvd/Bub1b^tm1Jvd, Emx1^tm1(cre)Krj/Emx1⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: cerebral cortex	Weak		5A BubR1 cKO	Expression reduced compared to wild type.

5A dcKO ©

Specimen 5A TBR2 dcKO: embryonic day 14.5; Bub1b^tm1Jvd/Bub1b^tm1Jvd, Emx1^tm1(cre)Krj/Emx1⁺, Trp53^tm1Brn/Trp53^tm1Brn (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: cerebral cortex	Present		5A dcKO	Expression fully rescued to wild type levels.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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