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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548368
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody
Results
Specimen 3A CC3 WT: embryonic day 14.5 (more )
Note: Double labeled: red - Casp3; green - Foxm1 (assay MGI:7548370).
Structure Level Pattern Image Note
TS22: cerebral cortex Ambiguous 3A WT , 3A WT inset Authors report a lack of significant cell death in wild type and Trp53 cKO groups.
Specimen 3A CC3 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Foxm1 (assay MGI:7548370).
Structure Level Pattern Image Note
TS22: cerebral cortex Ambiguous 3A Trp53 cKO , 3A Trp53 cKO inset Authors report a lack of significant cell death in wild type and Trp53 cKO groups.
Specimen 3A CC3 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Foxm1 (assay MGI:7548370).
Structure Level Pattern Image Note
TS22: cerebral cortex Strong 3A BubR1 cKO inset , 3A BubR1 cKO Significant increase in expressing cells compared to wild type.
Specimen 3A CC3 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Foxm1 (assay MGI:7548370).
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3A dcKO inset , 3A dcKO Expression significantly reduced compared to BubR1 cKO.
Specimen 3J CC3 WT: embryonic day 14.5 (more )
Note: Double labeled: red - Casp3; green - H2ax (assay MGI:7548372).
Structure Level Pattern Image Note
TS22: cerebral cortex Ambiguous 3J WT Authors report a lack of significant cell death in wild type and Trp53 cKO groups.
Specimen 3J CC3 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - H2ax (assay MGI:7548372).
Structure Level Pattern Image Note
TS22: cerebral cortex Ambiguous 3J Trp53 cKO Authors report a lack of significant cell death in wild type and Trp53 cKO groups.
Specimen 3J CC3 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - H2ax (assay MGI:7548372).
Structure Level Pattern Image Note
TS22: cerebral cortex Strong 3J BubR1 cKO Significant increase in expressing cells compared to wild type.
Specimen 3J CC3 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - H2ax (assay MGI:7548372).
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3J dcKO Expression significantly reduced compared to BubR1 cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory