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Gene Expression Data
Assay Details
Assay
Reference: J:231945 Dina C, et al., Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct;47(10):1206-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7547098
Gene symbol: Col1a1
Gene name: collagen, type I, alpha 1
Antibody: anti-Collagen Type I anti-Mouse (203002-1)
Detection system: Secondary antibody
Assay notes: The specificity of the antibody/probe used was not detailed; both family members have been annotated.
Results
Specimen 3c +/+: postnatal month 9 (more )
Note: Double labeled: red - Col1a1 and Col1a2; green - proteoglycans.
Structure Level Pattern Image Note
TS28: mitral valve Present 3c +/+
Specimen 3c -/-: postnatal month 9; Tns1tm1Efu/Tns1tm1Efu (more )
Note: Double labeled: red - Col1a1 and Col1a2; green - proteoglycans.
Structure Level Pattern Image Note
TS28: mitral valve Present 3c -/- Myxomatous degeneration, as indicated by increased proteoglycan content and loss of normal matrix stratification, was seen in the mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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