About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:249803 Guerrero-Flores G, et al., Functional determination of the differentiation potential of ventral mesencephalic neural precursor cells during dopaminergic neurogenesis. Dev Biol. 2017 Sep 1;429(1):56-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7538886
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Results
Specimen E9.5: embryonic day 9.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS15: future midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E10.5: embryonic day 10.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS17: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E11.5: embryonic day 11.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS19: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E12.0: embryonic day 12.0 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS20: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells.
Specimen E12.5: embryonic day 12.5 (more )
Note: Data not shown. Cell counts were graphed in Figure 1A.
Structure Cell Type Level Pattern Image Note
TS20: midbrain neural progenitor cell Present Regionally restricted Expression was detected in the dividing midbrain dopaminergic neural progenitor cells. The number of Sox2+ cells increased linearly through E9.5 to E12.5.
Specimen 1D: embryonic day 11.5 (more )
Note: Double labeled: red - Sox2; green - BrdU.
Structure Level Pattern Image Note
TS20: brain subventricular zone Present 1D BrdU/Sox2 All of the BrdU+ cells were also Sox2+.
TS20: brain ventricular layer Present 1D BrdU/Sox2 All of the BrdU+ cells were also Sox2+.
Specimen S1B: embryonic day 12.5 (more )
Note: BrdU at E10.5. Triple labeled: red - Sox2; blue - Lmx1a (assay MGI:7538898); green - BrdU.
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted S1B Sox2 , S1B Merge top Most BrdU+ cells co-expressed Sox2, some of which displayed a weak signal.
Specimen S2A left: embryonic day 10.5 (more )
Note: Double labeled: green - Sox2; red - Lmx1a (assay MGI:7538898).
Structure Level Pattern Image Note
TS17: midbrain Present Regionally restricted S2A left Most cells in the Lmx1a+ domain were Sox2+.
Specimen S3A left: embryonic day 11.5 (more )
Note: Double labeled: green - Sox2; red - Lmx1a (assay MGI:7538898).
Structure Level Pattern Image Note
TS19: midbrain Present Regionally restricted S3A left Several Sox2+ cells were noted in the Lmx1a+ domain, and some Sox2-negative cells were detected in the most pial region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory