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Gene Expression Data
Assay Details
Assay
Reference: J:185975 Baker C, et al., Adrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heart. Biochem Biophys Res Commun. 2012 Jul 6;423(3):536-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7537183
Gene symbol: Gja1
Gene name: gap junction protein, alpha 1
Antibody: anti-Cx43
Detection system: Secondary antibody
Results
Specimen 1a/c: embryonic day 10.5 (more )
Note: The genotype could be either +/+ or +/-. Double labeled: red - Gja1; green - Hcn4 (assay MGI:7537184).
Structure Level Pattern Image Note
TS17: atrium cardiac muscle Present 1a , 1c
TS17: sinoatrial node Present Regionally restricted 1c Only marginal overlap with Hcn4-positive cells.
TS17: outflow tract cardiac muscle Present 1a
TS17: primitive ventricle cardiac muscle Present 1a
Specimen 1b/d: embryonic day 10.5; Dbhtm1Rpa/Dbhtm1Rpa (more )
Note: Double labeled: red - Gja1; green - Hcn4 (assay MGI:7537184).
Structure Level Pattern Image Note
TS17: outflow tract cardiac muscle Present 1b Staining intensity was substantially less than that observed in adrenergic-competent control hearts.
TS17: primitive ventricle cardiac muscle Present 1b Staining intensity was substantially less than that observed in adrenergic-competent control hearts.
TS17: atrium cardiac muscle Present 1b , 1d Staining intensity was substantially less than that observed in adrenergic-competent control hearts.
TS17: sinoatrial node Present 1b , 1d Staining intensity was substantially less than that observed in adrenergic-competent control hearts.
Specimen 2c/e: embryonic day 9.5 (more )
Note: The genotype could be either +/+ or +/-.
Structure Level Pattern Image Note
TS15: heart Present 2c , 2e
Specimen 2d/f: embryonic day 9.5; Dbhtm1Rpa/Dbhtm1Rpa (more )
Structure Level Pattern Image Note
TS15: heart Present 2f , 2d Similar as in the controls.
Specimen S1c/e: embryonic day 10.5 (more )
Note: The genotype could be either +/+ or +/-.
Structure Level Pattern Image Note
TS17: atrioventricular canal cardiac muscle Present S1e , S1c
Specimen S1d/f: embryonic day 10.5; Dbhtm1Rpa/Dbhtm1Rpa (more )
Structure Level Pattern Image Note
TS17: atrioventricular canal cardiac muscle Trace S1d , S1f Could be seen when image processing was adjusted to increase sensitivity.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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