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Gene Expression Data
Assay Details
Assay
Reference: J:85877 Seki T, et al., Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. 2003 Oct 3;93(7):682-9
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7524556
Gene symbol: Acvrl1
Gene name: activin A receptor, type II-like 1
Reporter: lacZ
Direct Detection
Results
Specimen 1a: embryonic day 8.5; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS13: allantois Present 1a
TS13: dorsal aorta Present 1a
TS13: vitelline vein Present 1a
TS13: endocardial tube Present 1a Expression in endocardium.
Specimen 1b: embryonic day 9.5; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS15: dorsal aorta Present 1b
TS15: intersomitic artery Present 1b
TS15: blood vessel Present Regionally restricted 1b Expression in some capillaries.
Specimen 1e: embryonic day 11.5; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS19: dorsal aorta endothelium Present 1e
TS19: cardinal vein Absent 1e
Specimen 1f: embryonic day 11.5; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS19: dorsal aorta Present 1f
TS19: intersomitic artery Present 1f
TS19: blood vessel Present Regionally restricted 1f Expression in capillaries surrounding neural tube.
TS19: vein Absent 1f Expression undetectable in veins.
Specimen 1h: postnatal newborn; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS27: internal thoracic artery Present 1h
TS27: artery Present Regionally restricted 1h Expression in connecting small arteries.
TS27: internal thoracic vein Absent 1h
Specimen 1i: embryonic day 18.5; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS26: lung Strong 1i
TS26: lung vascular element Strong Regionally restricted 1i Strong expression in alveolar capillaries.
TS26: external carotid artery Present Regionally restricted 1i Expression in major arteries.
TS26: internal carotid artery Present Regionally restricted 1i Expression in major arteries.
TS26: spinal artery Present Regionally restricted 1i Expression in major arteries.
TS26: vertebral artery Present Regionally restricted 1i Expression in major arteries.
TS26: liver Absent 1i
Specimen 1j: embryonic day 15.5; Acvrl1tm1Spo/Acvrl1+ (more )
Note: Double labeled: blue - Acvrl1 reporter; brown - Pecam1 (assay MGI:7524559).
Structure Cell Type Level Pattern Image Note
TS23: aorta aortic endothelial cell Present 1j
Specimen 1k: embryonic day 15.5; Acvrl1tm1Spo/Acvrl1+ (more )
Note: Double labeled: blue - Acvrl1 reporter; brown - Acta2 (assay MGI:7524560).
Structure Cell Type Level Pattern Image Note
TS23: carotid artery endothelial cell of artery Present 1k
Specimen 2a: embryonic day 15.5; Acvrl1tm1Spo/Acvrl1+ (more )
Note: Double labeled: blue - Acvrl1 reporter; brown - Pecam1 (assay MGI:7524559).
Structure Cell Type Level Pattern Image Note
TS23: lung vascular element lung endothelial cell Present 2a
Specimen 2b: postnatal adult; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: lung vascular element pulmonary capillary endothelial cell Present Regionally restricted 2b Expression in alveolar capillaries, but in fewer capillaries than in embryonic lung.
Specimen 2c: postnatal week 2; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS28: skin blood vessel Strong Regionally restricted 2c Strong expression in growing arteries.
TS28: vein Weak 2c
Specimen 2d: postnatal adult; Acvrl1tm1Spo/Acvrl1+ (more )
Structure Level Pattern Image Note
TS28: skin blood vessel Weak 2d Expression in adult blood vessels significantly decreased.
Specimen S1g: embryonic day 9.5; Acvrl1tm1Spo/Acvrl1tm1Spo (more )
Structure Level Pattern Image Note
TS15: blood vessel Absent S1g
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory