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Gene Expression Data
Assay Details
Assay
Reference: J:167262 Sumida H, et al., LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood. 2010 Dec 2;116(23):5060-70
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520054
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Antibody: anti-LYVE1
Detection system: Secondary antibody coupled to Alexa Fluor 594
Assay notes: Knock-outs were either female Lpar4<tm1Sati>/Lpar4<tm1Sati> or male Lpar4<tm1Sati>/Y. Both have been annotated.
Results
Specimen 6A: embryonic day 14.5 (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS22: lymph sac Present 6A
Specimen 6B Female: embryonic day 14.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is apparently normal. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS22: lymph sac Present 6B This mutant had significant dilation of the lymph sacs.
Specimen 6B Male: embryonic day 14.5; Lpar4tm1Sati/Y (more )
Note: This mutant is apparently normal.
Structure Level Pattern Image Note
TS22: lymph sac Present This mutant had significant dilation of the lymph sacs.
Specimen 6C Female: embryonic day 14.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is edematous. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS22: lymph sac Present 6C This mutant had significant dilation of the lymph sacs. The lymph sacs were significantly larger than those of apparently normal knock-outs.
Specimen 6C Male: embryonic day 14.5; Lpar4tm1Sati/Y (more )
Note: This mutant is edematous.
Structure Level Pattern Image Note
TS22: lymph sac Present This mutant had significant dilation of the lymph sacs. The lymph sacs were significantly larger than those of apparently normal knock-outs.
Specimen 6E: embryonic day 18.5 (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: ileum Present Regionally restricted 6E Expression is in submucosal lymphatic vessels in the ileum.
TS26: lymphatic vessel endothelium Present Regionally restricted 6E Expression is in submucosal lymphatic vessels in the ileum.
Specimen 6F Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is apparently normal. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: ileum Present Regionally restricted 6F Expression is in slightly enlarged submucosal lymphatic vessels in the ileum.
TS26: lymphatic vessel endothelium Present Regionally restricted 6F Expression is in slightly enlarged submucosal lymphatic vessels in the ileum.
Specimen 6F Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is apparently normal.
Structure Level Pattern Image Note
TS26: ileum Present Regionally restricted Expression is in slightly enlarged submucosal lymphatic vessels in the ileum.
TS26: lymphatic vessel endothelium Present Regionally restricted Expression is in slightly enlarged submucosal lymphatic vessels in the ileum.
Specimen 6G Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is edematous. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: ileum Present Regionally restricted 6G In this mutant the subserosal lymphatic capillaries were absent and many of the lymphatics of the submucosal plexus were severely enlarged compared to wild-type.
TS26: lymphatic vessel endothelium Present Regionally restricted 6G In this mutant the subserosal lymphatic capillaries were absent and many of the lymphatics of the submucosal plexus were severely enlarged compared to wild-type.
Specimen 6G Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is edematous.
Structure Level Pattern Image Note
TS26: ileum Present Regionally restricted In this mutant the subserosal lymphatic capillaries were absent and many of the lymphatics of the submucosal plexus were severely enlarged compared to wild-type.
TS26: lymphatic vessel endothelium Present Regionally restricted In this mutant the subserosal lymphatic capillaries were absent and many of the lymphatics of the submucosal plexus were severely enlarged compared to wild-type.
Specimen 6H: embryonic day 18.5 (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present 6H
Specimen 6I Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is apparently normal. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present 6I This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen 6I Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is apparently normal.
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen 6J Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is edematous. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present 6J This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen 6J Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is edematous.
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen S3B: embryonic day 18.5 (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present S3D , S3B
Specimen S3F Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is apparently normal. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present S3H , S3F This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen S3F Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is apparently normal.
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen S3J Female: embryonic day 18.5; Lpar4tm1Sati/Lpar4tm1Sati (more )
Note: This mutant is edematous. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:7520002).
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present S3L , S3J This mutant had enlarged lymphatics as compared to wild-type embryos.
Specimen S3J Male: embryonic day 18.5; Lpar4tm1Sati/Y (more )
Note: This mutant is edematous.
Structure Level Pattern Image Note
TS26: lymphatic vessel endothelium Present This mutant had enlarged lymphatics as compared to wild-type embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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