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Gene Expression Data
Assay Details
Assay
Reference: J:338018 Stathopoulou A, et al., CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
Assay type: RNA in situ
MGI Accession ID: MGI:7512998
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Results
Specimen S4A,A': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch Present Regionally restricted S4A , S4A' Expression in distal portion of branchial arches.
TS15: secondary heart field Present S4A' , S4A
TS15: outflow tract Present S4A' , S4A
Specimen S4A'': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: primitive ventricle Present Regionally restricted S4A'' Expression in right ventricle.
Specimen S4A''': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: outflow tract Present S4A'''
TS15: pericardium Present Regionally restricted S4A''' Expression in dorsal pericardial wall.
Specimen S4B,B': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Present S4B , S4B'
TS15: secondary heart field Weak S4B' , S4B Expression significantly reduced, especially in second heart field.
TS15: outflow tract Weak S4B , S4B' Expression significantly reduced, especially in outflow tract.
Specimen S4B'': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: primitive ventricle Present Regionally restricted S4B'' Expression in right ventricle.
Specimen S4B''': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: outflow tract Weak S4B''' Expression significantly reduced, especially in outflow tract.
TS15: pericardium Weak Regionally restricted S4B''' Reduced expression in dorsal pericardial wall.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory