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Gene Expression Data
Assay Details
Assay
Reference: J:338018 Stathopoulou A, et al., CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
Assay type: RNA in situ
MGI Accession ID: MGI:7512990
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Results
Specimen 3C,C': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch Present 3C' , 3C
TS15: secondary heart field Present 3C , 3C'
Specimen 3C'': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: heart Present 3C''
Specimen 3C''': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: outflow tract Present 3C'''
TS15: pericardium Present Regionally restricted 3C''' Expression in dorsal pericardial wall.
Specimen 3D,D': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Weak Regionally restricted 3D , 3D' Reduced expression in branchial arches, especially 2nd arch.
TS15: secondary heart field Present Regionally restricted 3D' , 3D Expression in lateral part of second heart field not severely affected.
Specimen 3D'': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: heart Present 3D''
Specimen 3D''': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: outflow tract Present 3D'''
TS15: pericardium Present Regionally restricted 3D''' Expression in dorsal pericardial wall.
Specimen S3E,E': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch Present S3E , S3E'
Specimen S3F,F': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Weak Regionally restricted S3F' , S3F Reduced expression in branchial arches, especially 2nd arch.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory