About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:338018 Stathopoulou A, et al., CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
Assay type: RNA in situ
MGI Accession ID: MGI:7512990
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Results
Specimen 3C,C': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch Present 3C' , 3C
TS15: secondary heart field Present 3C , 3C'
Specimen 3C'': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: heart Present 3C''
Specimen 3C''': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: outflow tract Present 3C'''
TS15: pericardium Present Regionally restricted 3C''' Expression in dorsal pericardial wall.
Specimen 3D,D': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Weak Regionally restricted 3D , 3D' Reduced expression in branchial arches, especially 2nd arch.
TS15: secondary heart field Present Regionally restricted 3D' , 3D Expression in lateral part of second heart field not severely affected.
Specimen 3D'': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: heart Present 3D''
Specimen 3D''': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: outflow tract Present 3D'''
TS15: pericardium Present Regionally restricted 3D''' Expression in dorsal pericardial wall.
Specimen S3E,E': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch Present S3E , S3E'
Specimen S3F,F': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch Weak Regionally restricted S3F' , S3F Reduced expression in branchial arches, especially 2nd arch.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory