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Gene Expression Data
Assay Details
Assay
Reference: J:338018 Stathopoulou A, et al., CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
Assay type: RNA in situ
MGI Accession ID: MGI:7512989
Gene symbol: Fgf10
Gene name: fibroblast growth factor 10
Results
Specimen 3A,A': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: secondary heart field Present 3A , 3A'
TS15: primitive ventricle Weak Regionally restricted 3A' , 3A Weak expression in right ventricle.
Specimen 3A'': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Present 3A'' Expression in mesodermal core of branchial arches.
TS15: secondary heart field Present 3A''
TS15: primitive ventricle Weak Regionally restricted 3A'' Weak expression in right ventricle.
Specimen 3A''': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: pericardium Present Regionally restricted 3A''' Expression in dorsal pericardial wall.
Specimen 3B,B': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Absent 3B , 3B' Expression lost in second heart field.
TS15: primitive ventricle Trace Regionally restricted 3B , 3B' Reduced expression in right ventricle.
Specimen 3B'': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: branchial arch mesenchyme Weak 3B'' Reduced expression in mesoderm of branchial arches.
TS15: secondary heart field Absent 3B'' Expression lost in second heart field.
TS15: primitive ventricle Trace Regionally restricted 3B'' Reduced expression in right ventricle.
Specimen 3B''': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: pericardium Trace Regionally restricted 3B''' Minimal expression in dorsal pericardial wall.
Specimen S3A,A': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: secondary heart field Present S3A , S3A'
Specimen S3A'',A''': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: pericardium Present Regionally restricted S3A''' , S3A'' Expression in dorsal pericardial wall.
Specimen S3B,B': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Absent S3B , S3B' Expression lost in second heart field.
Specimen S3B'',B''': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: pericardium Trace Regionally restricted S3B''' , S3B'' Minimal expression in dorsal pericardial wall.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory