About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:321845 Bernhardt N, et al., Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. eNeuro. 2022 Mar-Apr;9(2):ENEURO.0518-21.2022
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7509788
Gene symbol: Nkx2-2
Gene name: NK2 homeobox 2
Antibody: anti-Nkx2.2
Assay notes: Two Rbfox3 antibodies were described, but the one used in this assay was not detailed. Anti-NeuN MGI:7509750 may have been used in this assay.
Results
Specimen 6J/J': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord lumbar region Present Regionally restricted 6J' , 6J Expression in ventral most V3 progenitor domain.

Specimen 6K/K': embryonic day 12.5; Ift56hop/Ift56hop (more )
Structure Level Pattern Image Note
TS20: spinal cord lumbar region Absent 6K' , 6K Ventral most V3 progenitor domain undetectable at lumbar levels

Specimen not shown: embryonic day 12.5; Ift56hop/Ift56hop (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted Loss of expression less apparent with increasing distance in both rostral and caudal directions.
TS20: spinal cord thoracic region Present Expression defect not found in thoracic region.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory