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Gene Expression Data
Assay Details
Assay
Reference: J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7509432
Gene symbol: Lgr5
Gene name: leucine rich repeat containing G protein coupled receptor 5
Reporter: GFP
Antibody: anti-GFP (ab6673)
Detection system: Secondary antibody
Results
Specimen 2B: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: intestine Present Single cells 2B bottom , 2B top Expression is in a few cells in the developing intestinal crypt base.

Specimen 3A Lgr5EGFP: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: intestine Present Single cells 3A Lgr5EGFP Expression is in a few stem cells in the developing intestinal crypt base.

Specimen 3A Lgr5KO: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa (more )
Structure Level Pattern Image Note
TS24: intestine Present Single cells 3A Lgr5KO Expression is in a few stem cells in the developing intestinal crypt base.

Specimen 3A Lgr4KO;Lgr5EGFP: embryonic day 16.5; Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa, Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: intestine Absent 3A Lgr4KO;Lgr5EGFP

Structure Level Pattern Image Note
TS24: intestine Absent 3A Lgr4/5dKO

Specimen 4B: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Cell Type Level Pattern Image Note
TS24: hair follicle Present 4B
TS24: dermis fibroblast of dermis Present 4B Expression is in dermal fibroblasts.

Specimen 4J Lgr5EGFP: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: hair follicle Present 4J Lgr5EGFP

Specimen 4J Lgr4KO;Lgr5EGFP: embryonic day 16.5; Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa, Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: hair follicle Present 4J Lgr4KO;Lgr5EGFP

Specimen 4J Lgr5KO: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa (more )
Structure Level Pattern Image Note
TS24: hair follicle Present 4J Lgr5KO

Structure Level Pattern Image Note
TS24: hair follicle Absent 4J Lgr4/5dKO

Specimen 5B: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: renal tubule Present Regionally restricted 5B right , 5B left Expression is in the tubular epithelium.
TS24: Bowman's capsule of maturing renal corpuscle Absent 5B right , 5B left

Specimen 5G Lgr5EGFP: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: renal tubule Present Regionally restricted 5G Lgr5EGFP Expression is in the tubular epithelium.

Specimen 5G Lgr4KO;Lgr5EGFP: embryonic day 16.5; Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa, Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Level Pattern Image Note
TS24: renal tubule Present Regionally restricted 5G Lgr4KO;Lgr5EGFP Expression is in the tubular epithelium.

Specimen 5G Lgr5KO: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa (more )
Structure Level Pattern Image Note
TS24: renal tubule Present Regionally restricted 5G Lgr5KO Expression is in the tubular epithelium.

Structure Level Pattern Image Note
TS24: renal tubule Present Regionally restricted 5G Lgr4/5dKO Expression is in the tubular epithelium.

Specimen S6A Lgr5EGFP: embryonic day 16.5; Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Cell Type Level Pattern Image Note
TS24: dermis fibroblast of dermis Present Regionally restricted S6A Lgr5EGFP Expression is in dermal fibroblasts.

Specimen S6A Lgr4KO; Lgr5EGFP: embryonic day 16.5; Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa, Lgr5tm1.1(cre/ERT2)Npa/Lgr5+ (more )
Structure Cell Type Level Pattern Image Note
TS24: dermis fibroblast of dermis Present Regionally restricted S6A Lgr4KO;Lgr5EGFP Expression is in dermal fibroblasts.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory