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Gene Expression Data
Assay Details
Assay
Reference: J:218695 Soggia A, et al., von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A upregulation. Diabetologia. 2014 Nov;57(11):2348-56
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7492349
Gene symbol: Hif1a
Gene name: hypoxia inducible factor 1, alpha subunit
Results
Specimen 1a/S1 E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: pancreas primordium Present Widespread 1a E10.5 , S1_HIF1-a E10.5 Widely expressed in pancreatic epithelium.
Specimen 1a/S1 E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: pancreas primordium epithelium Present Widespread 1a E11.5 , S1_HIF1-a E11.5 Widely expressed in pancreatic epithelium.
Specimen 1a/S1 E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pancreas epithelium Present Widespread 1a E12.5 , S1_HIF1-a E12.5 , S1_HIF1-a E12.5 inset Widely expressed in pancreatic epithelium.
Specimen 1a/S1 E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: pancreas epithelium Weak Regionally restricted 1a E13.5 , S1_HIF1-a E13.5 , S1_HIF1-a E13.5 inset Expression decreased sharply, restricted to tips of branched epithelia.
Specimen 1a/S1 E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: pancreas epithelium Weak Regionally restricted 1a E15.5 , S1_HIF1-a E15.5 Expression decreased sharply, restricted to tips of branched epithelia.
Specimen 1a E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: pancreas Trace Single cells 1a E17.5 Expressing cells only rarely detected.
Specimen 2b Control: embryonic day 17.5; Vhltm1Jae/Vhltm1Jae (more )
Structure Level Pattern Image Note
TS25: pancreas Absent 2b Control Expression undetectable in control.
Specimen 2b Sox9-Cre: embryonic day 17.5; Sox9tm3(cre)Crm/Sox9+, Vhltm1Jae/Vhltm1Jae (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: pancreas Present 2b Sox9-Cre Expression increased compared to control.
Specimen S3c: embryonic day 18.5; Vhltm1Jae/Vhltm1Jae (more )
Structure Level Pattern Image Note
TS26: lung Ambiguous S3c
Specimen S3d: embryonic day 18.5; Sox9tm3(cre)Crm/Sox9+, Vhltm1Jae/Vhltm1Jae (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung Present Regionally restricted S3d Expression in morphologically altered lung.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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