Ret RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:167305 Sims-Lucas S, et al., Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 2011 Jan;240(1):240-9
Assay type:	RNA in situ
MGI Accession ID:	MGI:7488104
Gene symbol:	Ret
Gene name:	ret proto-oncogene

Probe:	Ret probe
Probe preparation:	Antisense labelled with digoxigenin RNA
Assay notes:	Controls were littermates.

Results

4A ©

Specimen 4A Control: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: ureteric bud	Present		4A	Expression is in elongated ureteric bud trunks and branches.

4B ©

Specimen 4B: embryonic day 11.5; Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni (more

)

Structure	Level	Pattern	Image	Note
TS19: ureteric bud	Present		4B	Expression in this mutant is comparable to controls.

4C ©

Specimen 4C: embryonic day 11.5; Fgfr1^tm1Jpa/Fgfr1^tm1Jpa, Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni, Tg(Pax3-cre)1Joe/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: ureteric bud	Present		4C	In this mutant the ureteric buds fail to elongate or branch and had small, unbranched buds.

4D ©

Specimen 4D: embryonic day 11.5; Fgfr1^tm1Jpa/Fgfr1^tm1Jpa, Fgfr2^tm3.1Lni/Fgfr2^tm3.1Lni, Tg(Pax3-cre)1Joe/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: ureteric bud	Present		4D	In this mutant the ureteric buds fail to elongate or branch although a subset had an anteriorly displaced secondary ureteric bud.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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